期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 217, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2021.111397
关键词
Sonodynamic therapy; Cationic phthalocyanines; Singlet oxygen; Radicals; Cancer cells; Ultrasound
资金
- Department of Science and Technology, Republic of South Africa
- National Research Foundation through DST/NRF South Africa Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [UID 62620]
- Rhodes University
The sonodynamic activity of cationic phthalocyanines was studied under different ultrasound parameters, with para-pyridine and morpholine groups showing better generation of reactive oxygen species. High levels of hydroxyl radicals were observed under certain conditions. However, the generation efficiency of reactive species decreased under specific parameters.
We report on the sonodynamic activity of cationic phthalocyanines (Pcs) and the effect of the variation of two parameters: ultrasound frequency and power (Par I (1 MHz, 1 W cm(-2)), Par II (1 MHz, 2 W cm(-2)), Par III (3 MHz, 1 W cm(-2)) and Par IV (3 MHz, 2 W cm(-2))) on the efficiency of their reactive oxygen species generation and cancer eradication in vitro thereof. Where Par stands for the various combinations of these parameters. Four Pcs were investigated with substituents bearing diethylamine, ortho-and para-pyridine and morpholine groups. Overall, the para-pyridine and morpholine Pcs showed substantial sono-activity in the various ultrasound parameters with Par I and IV generally showing better singlet oxygen and hydroxyl radicals generation confirmed by electron paramagnetic resonance spectroscopy. In some cases, very high hydroxyl radicals? generation was observed at Par II. Furthermore, the fragmentation of the Pcs after Par II treatments was confirmed using UV-vis and magnetic circular dichroism spectroscopy. The reactive species generation efficacy decreased at Par III for all samples. Ultrasound assisted cytotoxicity of the Pcs was confirmed in vitro using the human (Michigan Cancer Foundation-7) breast cancer cell line.
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