4.7 Article

Evaluation of the effects of low nanomolar bisphenol A-like compounds' levels on early human embryonic development and lipid metabolism with human embryonic stem cell in vitro differentiation models

期刊

JOURNAL OF HAZARDOUS MATERIALS
卷 407, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.jhazmat.2020.124387

关键词

Human embryonic stem cells (hESCs); Embryoid bodies (EBs); Bisphenols; Developmental Toxicity; Stem cell toxicology

资金

  1. National Natural Science Foundation of China [21876197, 21976203, 21707160]
  2. Chinese Academy of Sciences [QYZDJ-SSW-DQC017]
  3. K. C. Wong Education Foundation

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It was found that substitutes for BPA may have adverse effects on lineage commitment and lipid metabolism during early embryonic development, with BPE showing the mildest impact among the seven bisphenols analyzed.
The widely used chemical bisphenol A (BPA) has been associated with several health effects. In recent years, many derivatives were developed to replace BPA although without thorough toxicological evaluation. Here, we employed a human embryoid body (EB)-based in vitro global differentiation and hepatic specification models, followed by RNA-seq analyses, to comprehensively study the potential developmental toxicity of six BPA replacements (BPS, BPF, BPZ, BPB, BPE, and BPAF), as compared to BPA. We found that those bisphenols may disrupt lineage commitment and lipid metabolism during early embryonic development. These effects mostly manifested via the dysregulation of HOX and APO family genes. Moreover, among the seven bisphenols analyzed, BPE seemed to have the mildest effects.

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