期刊
JOURNAL OF HAZARDOUS MATERIALS
卷 407, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jhazmat.2020.124378
关键词
PFASs; F-53B; Estradiol; PFOS; Cohort
资金
- National Natural Science Foundation of China [22006046, 81372959, 21437002, 81402649, 41977326, 91643207]
- China Postdoctoral Science Foundation [2019M662645]
- National Key Research and Development Plan of China [2016YFC0206203, 2016YFC0206700]
The study revealed associations between PFASs and estrogens in newborns, with F-53B contributing significantly to these associations. Further toxicology studies are necessary to fully understand the effects of PFASs on estrogens and their mechanisms.
Experimental studies suggested perand polyfluoroalkyl substances (PFASs) may disrupt estrogens in animals, however, the epidemiological evidence on the associations of PFASs with estrogens is sparse. We investigated the associations of legacy PFASs and their alternatives, including F-53B, the perfluorooctane sulfonate (PFOS) replacement that is specifically and commonly used in China, with estrogen concentrations in newborns. We quantified six PFASs and three estrogens in the cord sera of 942 newborns from a birth cohort in Wuhan, China, between 2013 and 2014. After adjusting for confounders and correcting for multiple comparisons, we observed that both legacy PFASs and their alternatives were associated with higher serum levels of estradiol (E2). Some of the PFASs were associated with increasing levels of estrone (E1) and estriol (E3). Analysis of PFASs in mixture using weighted quantile sum regressions showed that F-53B contributed 20.1% and 48.5% to the associations between PFASs and E1 and E2, respectively. This study provided epidemiological data on the associations between common PFAS exposures and estrogens in newborns. Additional toxicology studies are needed to fully understand the effects of PFASs on estrogens and the mechanisms.
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