SARS-CoV-2 one year on: evidence for ongoing viral adaptation

Article Immunology

Natural Transmission of Bat-like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine-Arginine-Alanine Variants in Coronavirus Disease 2019 Patients

Yik Chun Wong et al.

Summary: The study found that bat-like SARS-CoV-2 (Delta PRRA) variants not only naturally exist in COVID-19 patients but also remain transmissible, which has significant implications for the zoonotic origin and natural evolution of SARS-CoV-2.

CLINICAL INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Spike mutation D614G alters SARS-CoV-2 fitness

Jessica A. Plante et al.

Summary: The D614G substitution in the SARS-CoV-2 spike protein enhances viral replication and infectivity in human lung epithelial cells, primary airway tissues, and hamsters. This variant may increase transmission in the upper respiratory tract and doesn't seem to significantly reduce vaccine efficacy. Further research on therapeutic antibodies targeting the circulating G614 virus is recommended.

NATURE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Erik Volz et al.

Summary: The study suggests a positive selection for the SARS-CoV-2 spike protein variant D614G in the UK, but no evidence of differences in COVID-19 mortality or clinical severity in patients infected with this variant. 614G is associated with higher viral load and younger age of patients compared to 614D.

CELL (2021)

添加到收藏夹

Article Microbiology

D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization

Drew Weissman et al.

Summary: The D614G mutation in the spike protein of SARS-CoV-2 is not expected to hinder current vaccine development, as viruses with the G614 spike are more susceptible to neutralization, indicating that the mutation may not affect vaccine efficacy.

CELL HOST & MICROBE (2021)

添加到收藏夹

Article Virology

Spike Glycoprotein and Host Cell Determinants of SARS-CoV-2 Entry and Cytopathic Effects

Hanh T. Nguyen et al.

Summary: The SARS-CoV-2 spike glycoprotein has evolved features such as the furin cleavage site and D614G mutation to balance virus infectivity, stability, cytopathicity, and antibody vulnerability, while the endodomain of the S2 subunit is not essential for virus entry or syncytium formation. Metalloprotease inhibitors can suppress S-mediated cell-cell fusion, but not virus entry, suggesting a role for host proteases in activating the S glycoprotein during syncytium formation. This understanding of SARS-CoV-2 S glycoprotein interactions with host cells provides insights into virus transmission and pathogenicity.

JOURNAL OF VIROLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

Bryan A. Johnson et al.

Summary: The genetic mutation in SARS-CoV-2 resulted in better fitness in some cells but lower replication capacity in human respiratory cell lines. Despite reducing disease symptoms, the Delta PRRA mutant provided protection against rechallenge with the wildtype SARS-CoV-2.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

Tyler N. Starr et al.

Summary: Research has found that mutations in the receptor binding domain (RBD) of SARS-CoV-2 may potentially escape the action of the REGN-COV2 cocktail, providing important information for interpreting mutations observed during viral surveillance.

SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic

Lewis F. Buss et al.

Summary: Research indicates that the attack rate of COVID-19 in Manaus, the capital of Amazonas state in northern Brazil, reached 66% in June 2020, rising to 76% by October, higher than the estimated attack rate of 29% in Sao Paulo, southeastern Brazil, during the same period.

SCIENCE (2021)

添加到收藏夹

Article Virology

Deletion in the C-terminal region of the envelope glycoprotein in some of the Indian SARS-CoV-2 genome

Ballamoole Krishna Kumar et al.

Summary: An analysis of 2086 whole genome sequences from India revealed extensive amino acid deletions in the C-terminal region of the envelope glycoprotein in 34 Indian SARS-CoV-2 genomes, possibly due to adaptation to new geographical areas and hosts. Further studies are needed to understand the functional consequences of these deletions on the viral pathogenesis and host adaptation. Clinical information was only available for 9 out of 34 cases, all of which were asymptomatic.

VIRUS RESEARCH (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity

Kathryn A. Ryan et al.

Summary: The study found that high doses of SARS-CoV-2 in ferrets can cause viral RNA shedding in the upper respiratory tract and lung pathology, while lower doses result in milder pathological symptoms. Ferrets re-challenged after virus shedding ceased are fully protected from acute lung pathology.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Microbiology

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

Michihito Sasaki et al.

Summary: This study identified SARS-CoV-2 variants with mutations at the cleavage motif of the S protein (S gene mutants) that undergo inefficient proteolytic cleavage, leading to smaller plaques and less infectivity. These mutants emerged rapidly through virus propagation in Vero cells and may have been unknowingly used in experiments, antiviral screenings, and vaccine development. The mutations affect the virus' entry pathway and cell tropism, emphasizing the importance of monitoring de novo S gene mutations during tissue-culture propagation.

PLOS PATHOGENS (2021)

添加到收藏夹

Article Biology

SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

Anna Z. Mykytyn et al.

Summary: The entry of coronavirus is mediated by the spike protein, which is cleaved by different proteases depending on cell lines. Studies have shown that the presence of a multibasic cleavage site (MBCS) in the SARS-CoV-2 spike protein increases infectivity in human airway cells. The virus enters cells using serine proteases, indicating that the MBCS may be an adaptation to this viral entry strategy.

ELIFE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

Emma C. Thomson et al.

Summary: SARS-CoV-2 virus can mutate and evade immunity, with mutations like N439K conferring resistance against neutralizing monoclonal antibodies and enhancing binding affinity to hACE2 receptor. Despite similar in vitro replication fitness and clinical outcomes compared to wild type, N439K mutation highlights the importance of ongoing molecular surveillance for guiding vaccine and therapeutic development and usage.

CELL (2021)

添加到收藏夹

Article Microbiology

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

Zhuoming Liu et al.

Summary: The study found that antibodies targeting the SARS-CoV-2 spike protein have escape mutations, different monoclonal antibodies have unique resistance profiles, some mutants are resistant to multiple antibodies while some variants can escape neutralization by convalescent sera. Comparing antibody-mediated mutations with circulating SARS-CoV-2 sequences revealed substitutions that may weaken neutralizing immune responses in some individuals, warranting further investigation.

CELL HOST & MICROBE (2021)

添加到收藏夹

Article Microbiology

Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

Allison J. Greaney et al.

Summary: The evolution of SARS-CoV-2 may impact the recognition of the virus by human antibody-mediated immunity, with mutations affecting antibody binding varying significantly among individuals and within the same individual over time. Despite this variability, mutations that greatly reduce antibody binding usually occur at specific sites in the RBD, with E484 being the most crucial. These findings can inform surveillance efforts for SARS-CoV-2 evolution in the future.

CELL HOST & MICROBE (2021)

添加到收藏夹

Editorial Material Immunology

Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies

Jie Hu et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

添加到收藏夹

Letter Medicine, General & Internal

Emergence of a Novel SARS-CoV-2 Variant in Southern California

Wenjuan Zhang et al.

Summary: The research focused on sequencing and phylogenetic analyses of SARS-CoV-2 isolates from symptomatic patients at Cedar-Sinai Medical Center in November-December 2020, providing insights into a surge in cases and hospitalizations during that period.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

添加到收藏夹

Article Virology

The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2

Helena Winstone et al.

Summary: The presence of a polybasic cleavage site in the spike protein of SARS-CoV-2 allows the virus to enter cells in a pH-independent manner, mitigating against IFITM-mediated restriction and promoting replication and transmission. Targeted depletion of IFITM2 expression alleviates potent inhibition of SARS-CoV-2 replication by type I IFNs. Therapeutic strategies targeting furin-mediated cleavage of the spike protein may reduce viral replication through the activity of type I IFNs.

JOURNAL OF VIROLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 spike D614G change enhances replication and transmission

Bin Zhou et al.

Summary: Research has shown that the D614G substitution in the spike protein of SARS-CoV-2 leads to increased binding and replication potential in humans, as well as significantly higher replication and transmissibility in different animal models, providing an explanation for the global prevalence of this variant in the COVID-19 pandemic.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier et al.

Summary: The B.1.1.7 variant of SARS-CoV-2 exhibited reduced neutralization by vaccines and antibodies from recovered COVID-19 patients, with a more substantial loss seen when introducing the E484K mutation. This mutation poses a threat to the efficacy of the BNT162b2 vaccine.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Detection of a SARS-CoV-2 variant of concern in South Africa

Houriiyah Tegally et al.

Summary: The article describes a newly emerged lineage of SARS-CoV-2, 501Y.V2, characterized by eight mutations in the spike protein, which may result in increased transmissibility or immune escape. This lineage originated in South Africa and quickly became dominant in Eastern Cape, Western Cape, and KwaZuluNatal provinces within weeks.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp et al.

Summary: Chronic infection with SARS-CoV-2 can lead to viral evolution and increased resistance to neutralizing antibodies in immunosuppressed individuals treated with convalescent plasma. During convalescent plasma therapy, there were significant shifts in the viral population structure and sensitivity, suggesting strong selection pressure on the virus during treatment.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2

Donald J. Benton et al.

Summary: Studies indicate that the G614 mutant spike adopts more open conformations, which may facilitate binding to the SARS-CoV-2 receptor ACE2 and the subsequent structural rearrangements required for viral membrane fusion.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

Kevin R. McCarthy et al.

Summary: The translation above discusses zoonotic pandemics caused by animal viruses spilling over into highly susceptible human populations, specifically focusing on the evolution of coronaviruses in human hosts and the impact of recurrent deletions in the spike glycoprotein on antibody epitopes. These studies help understand the antigenic evolution and adaptive evolution of SARS-CoV-2.

SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

Yunkai Zhu et al.

Summary: The SARS-CoV-2 spike protein contains a multi-basic cleavage site that affects virus entry and transmission, as shown in hamster models. Host factors affecting virus entry were identified through a genome-wide CRISPR screen.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

Seiya Ozono et al.

Summary: The naturally occurring mutations of SARS-CoV-2 spike protein can affect cell entry, with the D614G mutation resulting in increased cell entry and maintaining susceptibility to neutralization by antisera against prototypic viruses. Further global surveillance is needed to understand the transmissibility of SARS-CoV-2 among humans.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

News Item Medicine, General & Internal

Covid-19: The E484K mutation and the risks it poses

Jacqui Wise

BMJ-BRITISH MEDICAL JOURNAL (2021)

添加到收藏夹

Article Biology

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

Zharko Daniloski et al.

Summary: A novel variant of SARS-CoV-2 virus with mutation D614G has been found to be more effective at transducing human cells and showing increased infectivity in human cells compared to the wild-type variant.

ELIFE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity

Alex Graudenzi et al.

Summary: This study conducted a large-scale analysis of intra-host genomic diversity of SARS-CoV-2, revealing interactions between host-related mutational processes and transmission dynamics, as well as identifying mutational signatures related to nucleotide substitutions. The study also demonstrated the impact of purifying selection on these mutational processes, while some mutations transition towards clonality, increasing overall genomic diversity. Additionally, phylogenomic analysis supported the hypothesis of transmission of minor variants, paving the way for integrated analysis of intra-host genomic diversity and clinical outcomes of SARS-CoV-2 infections.

ISCIENCE (2021)

添加到收藏夹

Letter Immunology

Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil

Carolina Kymie Vasques Nonaka et al.

Summary: The case of reinfection from distinct virus lineages in Brazil with the E484K mutation raises concerns about the duration of protective immune responses against SARS-CoV-2, especially with the variant associated with escape from neutralizing antibodies. This highlights potential challenges for virus control measures.

EMERGING INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Host-directed editing of the SARS-CoV-2 genome

Tobias Mourier et al.

Summary: The extensive sequence data from SARS-CoV-2 in 2020 pandemic has facilitated the study of viral genome evolution, revealing instances of directional mutation pressures exerted on the genome by host antiviral defense systems. It discusses three human defense mechanisms – APOBEC, ADAR, and ROS – and their potential implications on SARS-CoV-2 evolution.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans

Bas B. Oude Munnink et al.

Summary: Animal experiments have shown that various animals can be infected by SARS-CoV-2, with evidence of animal-to-human transmission within mink farms. Investigation into mink farm outbreaks revealed that the virus was initially introduced by humans and has since evolved, causing transmission between mink farms. Despite enhanced biosecurity measures and culling, transmission occurred between farms in three large clusters with unknown modes of transmission, resulting in a high percentage of infections among mink farm residents and employees.

SCIENCE (2021)

添加到收藏夹

Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Letter Immunology

Isolation of SARS-CoV-2 strains carrying a nucleotide mutation, leading to a stop codon in the ORF 6 protein

Serena Delbue et al.

Summary: SARS-CoV-2 was isolated from two Italian COVID-19 patients with distinct disease courses, showing a nucleotide mutation in the ORF6 gene. This mutation did not impact viral replication or neutralizing activities of antibodies. The deletion in the ORF6 protein might play a specific, yet unknown role in the viral pathogenesis by affecting the interaction between the virus and antiviral interferon.

EMERGING MICROBES & INFECTIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

添加到收藏夹

Article Microbiology

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

Young-Il Kim et al.

CELL HOST & MICROBE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein

Hong Zhou et al.

CURRENT BIOLOGY (2020)

添加到收藏夹

Letter Virology

An 81-Nucleotide Deletion in SARS-CoV-2 ORF7a Identified from Sentinel Surveillance in Arizona (January to March 2020)

LaRinda A. Holland et al.

JOURNAL OF VIROLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2

Salvatore Di Giorgio et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Emergence of SARS-CoV-2 through recombination and strong purifying selection

Xiaojun Li et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

Tran Thi Nhu Thao et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

Tommy Tsan-Yuk Lam et al.

NATURE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding

Tyler N. Starr et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

Qianqian Li et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Bette Korber et al.

CELL (2020)

添加到收藏夹

Article Immunology

Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patients

Cristina Andres et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Article Microbiology

Rampant C -> U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories

P. Simmonds

MSPHERE (2020)

添加到收藏夹

Letter Virology

Identification of multiple large deletions in ORF7a resulting in in-frame gene fusions in clinical SARS-CoV-2 isolates

Amin Addetia et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

Natacha S. Ogando et al.

JOURNAL OF GENERAL VIROLOGY (2020)

添加到收藏夹

Article Virology

Identification of Common Deletions in the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2

Zhe Liu et al.

JOURNAL OF VIROLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

Leonid Yurkovetskiy et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

Alina Baum et al.

SCIENCE (2020)

添加到收藏夹

News Item Multidisciplinary Sciences

Coronavirus rips through Dutch mink farms, triggering culls

Martin Enserink

SCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

Hongjing Gu et al.

SCIENCE (2020)

添加到收藏夹

Article Microbiology

Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2

Yvonne C. F. Su et al.

MBIO (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 is transmitted via contact and via the air between ferrets

Mathilde Richard et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Genetics & Heredity

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein

Andrew D. Davidson et al.

GENOME MEDICINE (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients

William B. Klimstra et al.

JOURNAL OF GENERAL VIROLOGY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Emerging of a SARS-CoV-2 viral strain with a deletion in nsp1

Francesca Benedetti et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Virology

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2

Natacha S. Ogando et al.

JOURNAL OF VIROLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study

Barnaby E. Young et al.

LANCET (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

Donald J. Benton et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

Zunlong Ke et al.

NATURE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

Katharina Schubert et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic

Leszek J. Klimczak et al.

PLOS ONE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

Lisa Miorin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Virology

Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism

Shona C. Moore et al.

VIRUSES-BASEL (2020)

添加到收藏夹

Article Virology

Host Immune Response Driving SARS-CoV-2 Evolution

Rui Wang et al.

VIRUSES-BASEL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responses

Masato Kosuge et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Cell Biology

Evasion of Type I Interferon by SARS-CoV-2

Hongjie Xia et al.

CELL REPORTS (2020)

添加到收藏夹

Article Immunology

A SARS-CoV-2 variant with the 12-bp deletion at E gene

Yi-Sheng Sun et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Article Virology

Temporal signal and the phylodynamic threshold of SARS-CoV-2

Sebastian Duchene et al.

VIRUS EVOLUTION (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer

Victoria A. Avanzato et al.

CELL (2020)

添加到收藏夹

Letter Medicine, General & Internal

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

Bina Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Virology

Genomic surveillance of SARS-CoV-2 in Thailand reveals mixed imported populations, a local lineage expansion and a virus with truncated ORF7a

Khajohn Joonlasak et al.

VIRUS RESEARCH (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

Lizhou Zhang et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2

Lucy van Dorp et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins

Carina Conceicao et al.

PLOS BIOLOGY (2020)

添加到收藏夹

Article Microbiology

Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles

Akshamal M. Gamage et al.

PLOS PATHOGENS (2020)

添加到收藏夹

Article Medicine, General & Internal

A Clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways

Ramon Lorenzo-Redondo et al.

EBIOMEDICINE (2020)

添加到收藏夹

Article Immunology

SARS-CoV-2 genomic surveillance in Taiwan revealed novel ORF8-deletion mutant and clade possibly associated with infections in Middle East

Yu-Nong Gong et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations

Hsin-Chou Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

Yixuan J. Hou et al.

SCIENCE (2020)

添加到收藏夹

Article Immunology

Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal

Vitor Borges et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Mutations on COVID-19 diagnostic targets

Rui Wang et al.

GENOMICS (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease

Xiaofeng Dong et al.

GENOME BIOLOGY (2020)

添加到收藏夹

Article Infectious Diseases

Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study

Hin Chu et al.

LANCET MICROBE (2020)

添加到收藏夹

Article Immunology

Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

Siu-Ying Lau et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Decline of transmissible gastroenteritis virus and its complex evolutionary relationship with porcine respiratory coronavirus in the United States

Fangzhou Chen et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Immunology

Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential

Joshua E. Sealy et al.

EMERGING INFECTIOUS DISEASES (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid Ligands

Jason D. Salter et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Within-Host Evolution of Human Influenza Virus

Katherine S. Xue et al.

TRENDS IN MICROBIOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission

Doreen Muth et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Immunology

The molecular basis of antigenic variation among A(H9N2) avian influenza viruses

Thomas P. Peacock et al.

EMERGING MICROBES & INFECTIONS (2018)

添加到收藏夹

Article Virology

Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics

Thomas P. Peacock et al.

JOURNAL OF VIROLOGY (2017)

添加到收藏夹

Article Microbiology

Vaccination against infectious bronchitis virus: A continuous challenge

Brian Jordan

VETERINARY MICROBIOLOGY (2017)

添加到收藏夹

Article Microbiology

Genetic Predisposition To Acquire a Polybasic Cleavage Site for Highly Pathogenic Avian Influenza Virus Hemagglutinin

Naganori Nao et al.

MBIO (2017)

添加到收藏夹

Article Microbiology

Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity

Mark J. G. Bakkers et al.

CELL HOST & MICROBE (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

The APOBEC Protein Family: United by Structure, Divergent in Function

Jason D. Salter et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission

Zhao Zhang et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Virology

Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference

Justin K. Taylor et al.

JOURNAL OF VIROLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa

Miles W. Carroll et al.

NATURE (2015)

添加到收藏夹

Article Microbiology

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

Jose M. Jimenez-Guardeno et al.

PLOS PATHOGENS (2015)

添加到收藏夹

Review Virology

Receptor Recognition Mechanisms of Coronaviruses: a Decade of Structural Studies

Fang Li

JOURNAL OF VIROLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

Jean Kaoru Millet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Immunology

Mutation in Spike Protein Cleavage Site and Pathogenesis of Feline Coronavirus

Beth N. Licitra et al.

EMERGING INFECTIOUS DISEASES (2013)

添加到收藏夹

Article Virology

Characterization of a Highly Conserved Domain within the Severe Acute Respiratory Syndrome Coronavirus Spike Protein S2 Domain with Characteristics of a Viral Fusion Peptide

Ikenna G. Madu et al.

JOURNAL OF VIROLOGY (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

Sandrine Belouzard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift

Scott E. Hensley et al.

SCIENCE (2009)

添加到收藏夹

Article Virology

The 29-nucleotide deletion present in human but not in animal severe acute respiratory syndrome coronaviruses disrupts the functional expression of open reading frame 8

Monique Oostra et al.

JOURNAL OF VIROLOGY (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

A left-handed RNA double helix bound by the Zα domain of the RNA-editing enzyme ADAR1

Diana Placido et al.

STRUCTURE (2007)

添加到收藏夹

Article Virology

A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo

Marta L. DeDiego et al.

JOURNAL OF VIROLOGY (2007)

添加到收藏夹

Article Multidisciplinary Sciences

Discovery of an RNA virus 3′→5′ exoribonuclease that is critically involved in coronavirus RNA synthesis

E Minskaia et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

添加到收藏夹

Article Virology

7a protein of severe acute respiratory syndrome coronavirus inhibits cellular protein synthesis and activates p38 mitogen-activated protein kinase

SA Kopecky-Bromberg et al.

JOURNAL OF VIROLOGY (2006)

添加到收藏夹

Review Immunology

Toll-like receptors in innate immunity

K Takeda et al.

INTERNATIONAL IMMUNOLOGY (2005)

添加到收藏夹

Article Multidisciplinary Sciences

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

F Heil et al.

SCIENCE (2004)

添加到收藏夹

Article Virology

Intracellular targeting signals contribute to localization of coronavirus spike proteins near the virus assembly site

E Lontok et al.

JOURNAL OF VIROLOGY (2004)

添加到收藏夹

SARS-CoV-2 one year on: evidence for ongoing viral adaptation

相关参考文献

导出引文

分享论文