期刊
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
卷 31, 期 3, 页码 476-486出版社
SPRINGERNATURE
DOI: 10.1038/s41370-021-00335-3
关键词
Hair preparations; Personal care products; Estrogen receptor; Androgen receptor; Glucocorticoid receptor; Progesterone receptor
资金
- March of Dimes
- American Diabetes Association Minority Postdoctoral Fellowship
- National Institutes of Health [R01ES026166, T32ES007069, R01CA058420]
Hair products commonly used by Black women were found to exhibit hormonal activity, which could potentially impact health outcomes.
Background Certain types of hair products are more commonly used by Black women. Studies show hair products contain several endocrine-disrupting chemicals that are associated with adverse health outcomes. As chemical mixtures of endocrine disruptors, hair products may be hormonally active, but this remains unclear. Objective To assess the hormonal activity of commonly used Black hair products. Methods We identified six commonly used hair products (used by >10% of the population) from the Greater New York Hair Products Study. We used reporter gene assays (RGAs) incorporating natural steroid receptors to evaluate estrogenic, androgenic, progestogenic, and glucocorticoid hormonal bioactivity employing an extraction method using bond elution prior to RGA assessment at dilutions from 50 to 500. Results All products displayed hormonal activity, varying in the amount and effect. Three samples showed estrogen agonist properties at levels from 12.5 to 20 ng/g estradiol equivalent concentrations All but one sample showed androgen antagonist properties at levels from 20 to 25 ng/g androgen equivalent concentrations. Four samples showed antagonistic and agonistic properties to progesterone and glucocorticoid. Significance Hair products commonly used by Black women showed hormonal activity. Given their frequent use, exposure to hormonally active products could have implications for health outcomes and contribute to reproductive and metabolic health disparities.
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