4.7 Review

A review on traditional usages, chemical constituents and pharmacological activities of periploca forrestii schltr

期刊

JOURNAL OF ETHNOPHARMACOLOGY
卷 271, 期 -, 页码 -

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2021.113892

关键词

Periploca forrestii schlecht; Traditional uses; Phytochemistry; Pharmacology; Toxicology

资金

  1. Gannan Medical University [QD201909]
  2. school-level key projects - Gannan Medical University [ZD201912]
  3. Scientific Research Fund of Jiangxi Provincial Education Department [GJJ190827, GJJ201546]
  4. Natural Science Foundation of Jiangsu Province [SBK2018022608]

向作者/读者索取更多资源

Periploca forrestii, a classical medicinal plant in Miao medicine, has been used traditionally in the treatment of rheumatoid arthritis and traumatic injury. Modern pharmacological studies have shown its diverse bioactivities, but further research is needed to understand its mechanism of action and long-term effects.
Ethnopharmacological relevance: Periploca forrestii Schltr. was listed as a classical medicinal plant in Miao medicine, which is a branch of traditional Chinese medicine (TCM). According to the theory of TCM, P. forrestii has the efficacy of relaxing tendons and activating collaterals, and dispelling wind and eliminating dampness. Hence, it was often used for the therapy of rheumatoid arthritis and traumatic injury in clinical practice. Aims of the review: This review aims to present comprehensive information for the research progress of P. forrestii. The researches on botany, traditional uses, phytochemistry, pharmacology and toxicology of the plant are summarized. We mainly focus on the phytochemical and pharmacological investigations. As a representative class of phytochemicals in P. forrestii, more attention is paid to cardiac glycosides. The insights into potential action of mechanisms and possible future studies on P. forrestii are also discussed. Materials and methods: Relevant literature was acquired from scientific databases including Google Scholar, Web of Science, Scifinder, Baidu Scholar, PubMed and Chinese national knowledge infrastructure. Monographs and Chinese pharmacopoeia were also utilized as references. Results: To date, all kinds of phytochemical constituents have been isolated and identified from this plant including cardiac glycosides, steroids, terpenoids, flavonoids, phenylpropanoids, quinones, organic phenolic acids and others. Among these, cardiac glycosides were considered as the major ingredients and bioactive materials. Modern pharmacological studies demonstrated that the plant possessed extensive bioactivity, such as anti-inflammatory and analgesic effects, immunosuppressive action, wound healing activity, antioxidant, antitumor and, cardiotonic properties. Conclusions: As an important medicinal plant, lots of studies have proved that P. forrestii has significant therapeutical effects, especially on rheumatoid arthritis and traumatic injury. These results provide modern scientific evidence for traditional use and contribute to the development of novel remedies for chronic diseases. However, the exact mechanism of action remains to be elucidated. Furthermore, the long-term in vivo toxicity and clinical efficacy also require in-depth exploration in the future.

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