Natural polymeric nanocarriers in malignant glioma drug delivery and targeting

Among all central nervous diseases, malignant glioma is a crucial part that deserves more attention since high fatality and disability rate. There are several therapeutic strategies applied to the treatment of malignant glioma, especially certain chemotherapy-related treatments. However, the existence of the blood-brain barrier (BBB) seriously hinders the strategy's progress, so how to escape from the barriers is a fascinating question. Herein, we comprehensively discussed the details of malignant glioma and the BBB's functional morphology and summarised several routes bypassing the BBB. Additionally, since possessing excellent properties for drug delivery, we provided an insight into various promising natural polymeric materials and highlighted their applications in the treatment of malignant glioma.

Automated summary

Malignant glioma is a crucial part among all central nervous diseases, with high fatality and disability rates. Various therapeutic strategies, especially related to chemotherapy, are hindered by the blood-brain barrier. By studying ways to bypass the barrier and utilizing natural polymeric materials for drug delivery, advancements in treating malignant glioma are promising.