4.5 Review

Progress in tumour-targeted drug delivery based on cell-penetrating peptides

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Article Oncology

Highly penetrating nanobubble polymer enhances LINC00511-siRNA delivery for improving the chemosensitivity of triple-negative breast cancer

Yanchi Yuan et al.

Summary: The study successfully demonstrated the gene interference effect on triple-negative breast cancer cells by loading cell-penetrating peptides (CPP) into nanobubbles (CNBs) connected with LINC00511-siRNA, improving chemosensitivity.

ANTI-CANCER DRUGS (2021)

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A multicomponent-based microemulsion for boosting ovarian cancer therapy through dual modification with transferrin and SA-R6H4

Haijun Zhao et al.

Summary: The new microemulsion system enhances the therapeutic effect of tripterine on ovarian cancer cells, while reducing the toxicity of the drug on the liver and kidney. Dissolving tripterine in microemulsion could be a potential approach for safe and effective cancer therapy.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

Article Nanoscience & Nanotechnology

Intracellular Paclitaxel Delivery Facilitated by a Dual-Functional CPP with a Hydrophobic Hairpin Tail

Yuping Wei et al.

Summary: A novel positive CPP carrier P9 was developed to enhance PTX translocation and increase intracellular concentration of PTX, leading to a significant decrease in tumor cell viability.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Biophysics

Nanoparticles modified with cell penetrating peptides: Assessing adsorption on membranes containing acidic lipids

Maria Chiarpotti et al.

Summary: In this study, the adsorption of nanoparticles coated with CPP on membranes containing acidic lipids was characterized using a molecular theory. The results show that electrostatic interactions, modulated by entropic effects, provide the driving force and regulate the adsorption kinetics of CPP-coated particles on acidic membranes. Adsorption free energy profiles allow to quantify the adsorption energy, and reveal that nanoparticles attachment and detachment from the membrane surface are restrained by free energy barriers.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Chemistry, Multidisciplinary

Highly Efficient Photothermal Therapy with Cell-Penetrating Peptide-Modified Bumpy Au Triangular Nanoprisms using Low Laser Power and Low Probe Dose

Minji Ha et al.

Summary: The bumpy Au triangular nanoprisms (BATrisms) developed in this study enhance surface area, improve cellular penetration, and increase photothermal conversion efficiency, demonstrating significant therapeutic efficacy against breast cancer in vivo.

NANO LETTERS (2021)

Article Chemistry, Medicinal

Discovery of novel cell-penetrating and tumor-targeting peptide-drug conjugate (PDC) for programmable delivery of paclitaxel and cancer treatment

Xin Deng et al.

Summary: A novel PDC was synthesized to intelligently deliver paclitaxel, showing higher cellular uptake and cytotoxicity in experiments, with less toxicity to normal cells and the ability to overcome paclitaxel resistance. The results demonstrated that this new PDC had better in vivo anti-tumor efficacy than paclitaxel.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Physical

pH-dependent reversibly activatable cell-penetrating peptides improve the antitumor effect of artemisinin-loaded liposomes

Yinglan Yu et al.

Summary: Artemisinin, well known as an antimalarial drug, can also be used for inflammation and cancer treatment. Studies have shown that utilizing a reversibly activatable cell-penetrating peptide can enhance the concentration of artemisinin in tumors, leading to improved antitumor effects.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Article Chemistry, Multidisciplinary

Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery

Emma M. McErlean et al.

Summary: The study designed a new 15 amino acid linear peptide, termed CHAT, for high efficiency delivery of DNA into cells both in vitro and in vivo. This peptide demonstrated controlled release of nucleic acids, low cytotoxicity, and efficient cellular penetration.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Chemistry, Multidisciplinary

pH-Activatable cell penetrating peptide dimers for potent delivery of anticancer drug to triple-negative breast cancer

So Hee Nam et al.

Summary: The designed pH-activatable cell-penetrating peptide dimer LH2 with histidine residues is able to penetrate cells specifically in weak acidic conditions, delivering paclitaxel effectively into triple-negative breast cancer cells. Both non-covalent complexes (PTX-LH2(M)) and covalent conjugates (PTX-LH2(C)) of LH2 show strong antitumor effects in a triple-negative breast cancer grafted mouse model at extremely low dosages, indicating potential for targeted drug delivery and therapy.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Chemistry, Multidisciplinary

An Azide-Tethered Cremophor® ELP Surfactant Allowing Facile Post-Surface Functionalization of Nanoemulsions

Airi Saito et al.

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN (2020)

Article Engineering, Chemical

Therapeutic potential of a cell penetrating peptide (CPP, NP1) mediated siRNA delivery: Evidence in 3D spheroids of colon cancer cells

Khalsa Al-Husaini et al.

CANADIAN JOURNAL OF CHEMICAL ENGINEERING (2020)

Article Nanoscience & Nanotechnology

Targeting Pancreatic Cancer Cells and Stellate Cells Using Designer Nanotherapeutics in vitro

Chandra Kumar Elechalawar et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Article Biochemistry & Molecular Biology

Effective Therapeutic Drug Delivery by GALA3, an Endosomal Escape Peptide with Reduced Hydrophobicity

Chen Li et al.

JOURNAL OF MEMBRANE BIOLOGY (2020)

Review Materials Science, Multidisciplinary

Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy

Xing Guo et al.

PROGRESS IN MATERIALS SCIENCE (2020)

Article Biotechnology & Applied Microbiology

Development of elastin-like polypeptide for targeted specific gene delivery in vivo

Aena Yi et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Article Materials Science, Biomaterials

CD44-Mediated Methotrexate Delivery by Hyaluronan-Coated Nanoparticles Composed of a Branched Cell-Penetrating Peptide

Jisang Yoo et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Article Chemistry, Multidisciplinary

Improved melanoma suppression with target-delivered TRAIL and Paclitaxel by a multifunctional nanocarrier

Shiqi Huang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Biotechnology & Applied Microbiology

Matrix metalloprotein-triggered, cell penetrating peptide-modified star-shaped nanoparticles for tumor targeting and cancer therapy

Fangyuan Guo et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Article Nanoscience & Nanotechnology

In vitro and in vivo characterization of CPP and transferrin modified liposomes encapsulating pDNA

Bruna dos Santos Rodrigues et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

Article Chemistry, Multidisciplinary

Graphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance

Zhaoxu Tu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Pharmacology & Pharmacy

Nose-to-brain drug delivery system with ligand/cell-penetrating peptidemodified polymeric nano-micelles for intracerebral gliomas

Takanori Kanazawa et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

Article Chemistry, Multidisciplinary

Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression

Mao-Ze Wang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Biochemistry & Molecular Biology

A polylysine-polyhistidine fusion peptide for lysosome-targeted protein delivery

Takashi Iwasaki et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Chemistry, Multidisciplinary

A novel mitochondrial targeted hybrid peptide modified HPMA copolymers for breast cancer metastasis suppression

Qiuyi Li et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Review Pharmacology & Pharmacy

Cell-penetrating peptides in oncologic pharmacotherapy: A review

Nuno Vale et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Multidisciplinary Sciences

TAT-RasGAP317-326 kills cells by targeting inner-leaflet-enriched phospholipids

Marc Serulla et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Pharmacology & Pharmacy

Addressing BBB Heterogeneity: A New Paradigm for Drug Delivery to Brain Tumors

Jessica I. Griffith et al.

PHARMACEUTICS (2020)

Article Multidisciplinary Sciences

Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

Jason V. Gregory et al.

NATURE COMMUNICATIONS (2020)

Article Materials Science, Biomaterials

Peptide modified polycations with pH triggered lytic activity for efficient gene delivery

Xiaojing Chen et al.

BIOMATERIALS SCIENCE (2020)

Article Chemistry, Physical

Thermodynamics of cell penetrating peptides on lipid membranes: sequence and membrane acidity regulate surface binding

Pedro G. Ramirez et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2020)

Article Chemistry, Multidisciplinary

Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

Alexander R. Noedling et al.

CHEMICAL COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

TAT peptide-modified cisplatin-loaded iron oxide nanoparticles for reversing cisplatin-resistant nasopharyngeal carcinoma

Huanhuan Weng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Pharmacology & Pharmacy

Octa-arginine boosts the penetration of elastin-like polypeptide nanoparticles in 3D cancer models

Lisanne M. P. E. van Oppen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

Review Chemistry, Multidisciplinary

Cell-penetrating peptide: a means of breaking through the physiological barriers of different tissues and organs

Jiangkang Xu et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Article Biotechnology & Applied Microbiology

A chitosan-based cascade-responsive drug delivery system for triple-negative breast cancer therapy

Shiwei Niu et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

Review Pharmacology & Pharmacy

Cell penetrating peptides: the potent multi-cargo intracellular carriers

Kimia Kardani et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

Article Nanoscience & Nanotechnology

Effective oral delivery of gp100 plasmid vaccine against metastatic melanoma through multi-faceted blending-by-blending nanogels

Yurun Shen et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

Review Engineering, Chemical

Stimuli-Sensitive Cell Penetrating Peptide-Modified Nanocarriers

Federico Perche

PROCESSES (2019)

Article Chemistry, Inorganic & Nuclear

Improvement of Cancer Therapy by TAT Peptide Conjugated Gold Nanoparticles

Ali A. Taha et al.

JOURNAL OF CLUSTER SCIENCE (2019)

Article Biochemistry & Molecular Biology

Tumor gene therapy by systemic delivery of plasmid DNA with cell-penetrating peptides

Kadri Kunnapuu et al.

FASEB BIOADVANCES (2019)

Article Nanoscience & Nanotechnology

Polymeric Drug Delivery System with Actively Targeted Cell Penetration and Nuclear Targeting for Cancer Therapy

Qiaochu Hua et al.

ACS APPLIED BIO MATERIALS (2019)

Article Biochemistry & Molecular Biology

Photoswitching of Cell Penetration of Amphipathic Peptides by Control of alpha-Helical Conformation

Gyu Chan Kim et al.

BIOMACROMOLECULES (2018)

Article Biochemical Research Methods

Selective Uptake Into Drug Resistant Mammalian Cancer by Cell Penetrating Peptide-Mediated Delivery

Kate J. F. Carnevale et al.

BIOCONJUGATE CHEMISTRY (2018)

Article Pharmacology & Pharmacy

Improved anticancer efficacy of doxorubicin mediated by human-derived cell-penetrating peptide dNP2

Yucheng Xiang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Pharmacology & Pharmacy

Coated microneedles mediated intradermal delivery of octaarginine/BRAF siRNA nanocomplexes for anti-melanoma treatment

Wenyi Ruan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Chemistry, Multidisciplinary

Bifunctional peptide hybrids targeting the matrix of mitochondria

Annika Klimpel et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Review Pharmacology & Pharmacy

Tumor Microenvironment Targeted Nanotherapy

Clara Fernandes et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Neurosciences

Convection-Enhanced Delivery for Diffuse Intrinsic Pontine Glioma Treatment

Zhiping Zhou et al.

CURRENT NEUROPHARMACOLOGY (2017)

Review Pharmacology & Pharmacy

Cell-penetrating peptides with intracellular organelle targeting

Carmine Pasquale Cerrato et al.

EXPERT OPINION ON DRUG DELIVERY (2017)

Article Nanoscience & Nanotechnology

Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy

Yuping Wei et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

Review Chemistry, Multidisciplinary

Matrix-metalloproteinases as targets for controlled delivery in cancer: An analysis of upregulation and expression

Kyle J. Isaacson et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Review Clinical Neurology

Convection-Enhanced Delivery

A. M. Mehta et al.

NEUROTHERAPEUTICS (2017)

Article Engineering, Biomedical

Nuclear-Targeted Multifunctional Magnetic Nanoparticles for Photothermal Therapy

Haibao Peng et al.

ADVANCED HEALTHCARE MATERIALS (2017)

Review Anatomy & Morphology

The molecular mechanism for nuclear transport and its application

Yun Hak Kim et al.

ANATOMY & CELL BIOLOGY (2017)

Review Biotechnology & Applied Microbiology

From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery

William A. Banks

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Chemistry, Multidisciplinary

Covalent Attachment of Cyclic TAT Peptides to GFP Results in Protein Delivery into Live Cells with Immediate Bioavailability

Nicole Nischan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Biochemistry & Molecular Biology

Molecular Description of the LCST Behavior of an Elastin-Like Polypeptide

Nan K. Li et al.

BIOMACROMOLECULES (2014)

Article Chemistry, Multidisciplinary

Enzyme-triggered gelation: targeting proteases with internal cleavage sites

Steven C. Bremmer et al.

CHEMICAL COMMUNICATIONS (2014)

Review Chemistry, Multidisciplinary

A survey on Trojan Horse peptides: Opportunities, issues and controlled entry to Troy

Nian-Qiu Shi et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Review Pharmacology & Pharmacy

Is there a future for cell-penetrating peptides in oligonucleotide delivery?

Soo Hyeon Lee et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2013)

Review Gastroenterology & Hepatology

A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment

Minoti V. Apte et al.

GASTROENTEROLOGY (2013)

Review Biochemistry & Molecular Biology

Membrane Interacting Peptides: From Killers to Helpers

Erick J. Dufourc et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2012)

Article Biochemistry & Molecular Biology

Identification of a novel cell-penetrating peptide from human phosphatidate phosphatase LPIN3

Sangho Lim et al.

MOLECULES AND CELLS (2012)

Article Pharmacology & Pharmacy

Preparation of nanobubbles for ultrasound imaging and intracelluar drug delivery

Ye Wang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

Article Biochemistry & Molecular Biology

D-Maurocalcine, a Pharmacologically Inert Efficient Cell-penetrating Peptide Analogue

Cathy Poillot et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Pharmacology & Pharmacy

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

Samuel K. Lai et al.

ADVANCED DRUG DELIVERY REVIEWS (2009)

Review Oncology

Is Anticancer Drug Development Heading in the Right Direction?

Trevor W. Hambley

CANCER RESEARCH (2009)

Review Pharmacology & Pharmacy

Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases

Yuma Yamada et al.

ADVANCED DRUG DELIVERY REVIEWS (2008)

Review Medicine, General & Internal

Mechanisms of disease - Melanoma

Arlo J. Miller et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Biochemistry & Molecular Biology

Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes

ND Sonawane et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)