期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 64, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jddst.2021.102565
关键词
Thymoquinone; Chitosan; Solid lipid nanoparticles; Bioavailability study
资金
- Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fasttrack Research Funding Program
Chitosan modified solid lipid nanoparticles were developed to enhance the oral bioavailability of thymoquinone, showing optimized nanoparticles with good in vitro and ex vivo performance, strong mucoadhesive properties, and controlled drug release. The results indicated significantly improved oral bioavailability compared to thymoquinone suspension.
High lipophilicity, low bioavailability, and hostile gastrointestinal (GI) environment is the major concern in oral administration of thymoquinone (TQ). Herein, we developed chitosan (CS) modified solid lipid nanoparticles (SLNs) to improve oral bioavailability. SLNs were systematically optimized by using a three-factor three-level QbD approach. The optimized TQ-CS-SLNs were successfully evaluated for various in vitro and ex vivo experiments and further evaluated for its bioavailability in Wistar albino rats. The developed TQ-CS-SLNs showed particle size, polydispersity index, and drug entrapment in the range between 135.61 and 211.36 nm, 0.17-0.29, and 65.14-91.78 %. The zeta potential of TQ-CS-SLNs was found to be +12.52 +/- 1.21 mV. Moreover, TQ-CSSLNs showed a controlled release profile during 24 h of study. In addition, optimized TQ-CS-SLNs showed excellent mucoadhesion with 67.26 +/- 2.18 % mucoadhesive efficiency. The intestinal permeation and confocal microscopy revealed higher permeation of TQ-CS-SLNs compared to TQ suspension. Furthermore, bioavailability results revealed that the optimized TQ-CS-SLNs represents many fold improved oral bioavailability of TQ compared to TQ suspension. Therefore, from the findings, it was concluded that the CS-SLNs could be an effective nanoplatforms for improved oral bioavailability of TQ.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据