期刊
JOURNAL OF CYSTIC FIBROSIS
卷 20, 期 4, 页码 678-681出版社
ELSEVIER
DOI: 10.1016/j.jcf.2021.03.022
关键词
Chronic sinusitis; Microbiome; Microbial ecology; Staphylococcus aureus; Pseudomonas aeruginosa
资金
- Gilead Sciences
- National Institutes of Health through National Institute of Dental and Craniofacial Research [T90 DE 0227232]
A study on patients with cystic fibrosis (CF) and chronic rhinosinusitis (CRS) found that the sinuses of CF-CRS patients harbor diverse bacterial communities not fully captured by clinical culture. Bacterial communities dominated by Staphylococcus spp. showed significantly more diversity compared to those dominated by Pseudomonas spp. Younger patients exhibited a wider range of bacterial diversity, indicating potential differences in microbial dynamics with age.
Chronic rhinosinusitis (CRS) affects nearly all individuals with cystic fibrosis (CF) and is thought to serve as a reservoir for microbiota that subsequently colonize the lung. To better understand the microbial ecology of CRS, we generated a 16S rRNA gene sequencing profile of sinus mucus from CF-CRS patients. We show that CF-CRS sinuses harbor bacterial diversity not entirely captured by clinical culture. Culture data consistently identified the dominant organism in most patients, though lower abundance bacteria were not always identified. We also demonstrate that bacterial communities dominated by Staphylococcus spp. were significantly more diverse compared to those dominated by Pseudomonas spp. Diversity was not significantly associated with clinical factors or patient age, however, younger subjects yielded a much wider range of bacterial diversity. These data mirror bacterial community dynamics in the lung and provide additional insight into the role of sinus microbiota in chronic airway disease progression. (c) 2021 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据