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Electrospinning for drug delivery applications: A review

期刊

JOURNAL OF CONTROLLED RELEASE
卷 334, 期 -, 页码 463-484

出版社

ELSEVIER
DOI: 10.1016/j.jconrel.2021.03.033

关键词

Electrospinning; Drug delivery; Nanofibers; Tissue engineering; Controlled release

资金

  1. Dutch Province of Limburg
  2. Italian Ministry grant PRIN [2017E44A9P]

向作者/读者索取更多资源

Drug delivery devices are promising in maximizing therapeutic effects and minimizing undesired side effects. Electrospun nanofibers have unique features like biocompatibility and flexibility, making them efficient in delivering active principles for a wide range of drugs. The technique of electrospinning allows for easy tuning and endless combinations, potentially leading to personalized medicine.
Drug delivery devices are promising tools in the pharmaceutical field, as they are able to maximize the therapeutic effects of the delivered drug while minimizing the undesired side effects. In the past years, electrospun nanofibers attracted rising attention due to their unique features, like biocompatibility and broad flexibility. Incorporation of active principles in nanofibrous meshes proved to be an efficient method for in situ delivery of a wide range of drugs, expanding the possibility and applicability of those devices. In this review, the principle of electrospinning and different fields of applications are treated to give an overview of the recent literature, underlining the easy tuning and endless combination of this technique, that in the future could be the new frontier of personalized medicine.

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