期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 588, 期 -, 页码 40-49出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2020.12.053
关键词
Laminarin; Seaweed polysaccharide; Laminarin microgel and nanogel; Blood compatible
资金
- Scientific Research Commission of Canakkale Onsekiz Mart University [COMU FYL-2020-3258]
Laminarin (LAM), a marine polysaccharide with various bioactivities, shows great potential in biomedical applications. A facile method was developed to prepare poly(laminarin) (p(LAM)) particles, which exhibited excellent blood compatibility and chemical modifiability. The synthesized p(LAM) particles hold promise as natural alternative surrogates in drug delivery and other biomedical applications.
Hypothesis: Laminarin (LAM) as a nontoxic, biodegradable, and biocompatible marine polysaccharide, has been reported for its ingenious bioactivities such as antioxidant, antitumor antiapoptotic antiinflammatory, immunomodulatory and dietary fiber activities, and distinct physicochemical structure possess a remarkably promising potential in biomaterial science. Synthesis of LAM-based microgels and bulk hydrogels have been reported in two stages: modification of LAM polysaccharide with polymerizable functional groups and subsequent crosslinking reaction. Therefore, here an easier and more effortless methods to prepare poly(laminarin) (p(LAM)) particles were tackled. Experimental: A direct and facile single step fabrication of micro/nanogels of p(LAM) for the first time by means of reverse micelle microemulsion system were illustrated. Preparation of p(LAM) particles were achieved by the well-known Oxa-Michael addition reaction mechanism using divinyl sulfone as the crosslinker. Findings: P(LAM) particles in 0.3-10 mm size range in spherical morphologies were prepared with 93 +/- 7% yield and functionalized with chlorosulfonic acid (CSA) demonstrating their chemical modifiability for variety of agents e.g., targeting ligands. The bare and modified p(LAM) particles showed excellent blood compatibility with hemolytic indices of <1% and blood clotting indices higher than 90%. The reported p(LAM) particles hold great promise as natural alternative surrogates in biomedical applications including drug delivery. (c) 2020 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据