期刊
JOURNAL OF CLUSTER SCIENCE
卷 33, 期 4, 页码 1427-1433出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10876-021-02070-z
关键词
Selenium nanoparticles; CIRI; Gallic acid
This study developed a delivery system of selenium nanoparticles loaded with gallic acid (GA-SeNPs) for the treatment of cerebral ischemia-reperfusion injury, showing potential efficacy in vitro experiments.
Ischemic stroke (IS) is a usual cerebrovascular ailment having high mortality and morbidity globally. The approaches for the treatment and prevention of cerebral ischemia-reperfusion injury (CIRI) are very limited. In this study, a delivery system of selenium nanoparticles loaded with gallic acid (GA-SeNPs) was developed utilizing ascorbic acid (AA) as a reducing agent and gallic acid (GA) as a capping agent. In pharmacokinetic study, GA-SeNPs clearly increases the AUC of the plasma concentration-time and extended GA half-life. In vitro effects of GA-SeNPs in the middle cerebral artery occlusion (MCAO) model and the oxygen glucose deprivation (OGD) model was measured. Finally, GA-SeNPs can be utilized as an efficient vehicle for delivery of GA in CIRI treatment.
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