期刊
JOURNAL OF CLINICAL IMMUNOLOGY
卷 41, 期 6, 页码 1146-1153出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-021-01046-y
关键词
Antibody deficiency; adaptive immune response; COVID-19; common variable immunodeficiency; SARSCoV-2; T cell response
类别
资金
- Jeffrey Modell Foundation
- Board of Visitors of the Children's National Health System
- Katzen Foundation
- Connor Family Foundation
- National Institute of Allergy and Infectious Diseases
- National Institute of Dental and Craniofacial Research
- National Cancer Institute, National Institutes of Health [75N91019D00024, 75N91020F00005]
- National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under BCBB Support Services [HHSN316201300006W/HHSN27200002]
This study characterized antibody and T cell responses to SARS-CoV-2 structural proteins in patients with antibody deficiencies, showing robust T cell activity and humoral immunity in some patients. The study results are encouraging, especially considering the reliance on spike protein in most candidate vaccines, but further research is needed to define the timing of immunity onset, longevity of immune response, and variability in immunocompromised patients.
Immunocompromised patients, including those with inborn errors of immunity (IEI), may be at increased risk for severe or prolonged infections with SARS-CoV-2 (Zhu et al. N Engl J Med. 382:727-33, 2020; Guan et al. 2020; Minotti et al. J Infect. 81:e61-6, 2020). While antibody and T cell responses to SARS-CoV-2 structural proteins are well described in healthy convalescent donors, adaptive humoral and cellular immunity has not yet been characterized in patients with antibody deficiency (Grifoni et al. Cell. 181:1489-1501 e1415, 2020; Burbelo et al. 2020; Long et al. Nat Med. 26:845-8, 2020; Braun et al. 2020). Herein, we describe the clinical course, antibody, and T cell responses to SARS-CoV-2 structural proteins in a cohort of adult and pediatric patients with antibody deficiencies (n = 5) and controls (related and unrelated) infected with SARSCoV-2. Five patients within the same family (3 with antibody deficiency, 2 immunocompetent controls) showed antibody responses to nucleocapsid and spike proteins, as well as SARS-CoV-2 specific T cell immunity at days 65-84 from onset of symptoms. No significant difference was identified between immunocompromised patients and controls. Two additional unrelated, adult patients with common variable immune deficiency were assessed. One did not show antibody response, but both demonstrated SARS-CoV-2-specific T cell immunity when evaluated 33 and 76 days, respectively, following SARSCoV-2 diagnosis. This report is the first to show robust T cell activity and humoral immunity against SARS-CoV-2 structural proteins in some patients with antibody deficiency. Given the reliance on spike protein in most candidate vaccines (Folegatti et al. Lancet. 396:467-78, 2020; Jackson et al. N Engl J Med. 383:1920-31, 2020), the responses are encouraging. Additional studies will be needed to further define the timing of onset of immunity, longevity of the immune response, and variability of response in immunocompromised patients.
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