期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 106, 期 9, 页码 E3565-E3572出版社
ENDOCRINE SOC
DOI: 10.1210/clinem/dgab338
关键词
N-6 polyunsaturated fatty acids; linoleic acid; arachidonic acid; age-related macular degeneration; Mendelian randomization
资金
- National Natural Science Foundation of China [81870641, 81970779, 82070939]
- Key Research and Development Project of Zhejiang Province [2020C03035]
The study found that circulating linoleic acid (LA) accounted for the protective effects of n-6 PUFAs against age-related macular degeneration (AMD), while arachidonic acid (AA) was associated with an increased risk of AMD.
Context: Although the role of n-6 polyunsaturated fatty acids (PUFAs) in age-related macular degeneration (AMD) has been studied in previous observational studies, the precise manner in which 1 or more n-6 PUFAs account for this relationship remains unclear. Objective: Using genetic instruments for n-6 PUFAs traits implemented through mendelian randomization (MR), we aimed to study possible causal associations between n-6 PUFAs and AMD. Methods: The 2-sample MR method was used to obtain unconfounded causal estimates. We selected genetic variants strongly associated (P < 5 x 10(-8)) with circulating linoleic acid (LA) and arachidonic acid (AA) from a study involving 8631 individuals and applied to an AMD case-control study (33 526 participants and 16 144 cases). The weighted median and MR Egger methods were used for the sensitivity analysis. Results: Our MR analysis suggested that circulating LA was a causal protective factor for AMD, with an odds ratio (OR) estimate of 0.967 (95% CI 0.945 to 0.990; P = .005) per percentage in total fatty acid increase in LA. In contrast, higher genetically predicted circulating AA causally increased the AMD risk (OR = 1.034; 95% CI 1.012 to 1.056; P = .002). Sensitivity analysis provided no indication of unknown pleiotropy.The findings from different single-nucleotide polymorphism selections and analytic methods were consistent, suggesting the robustness of the causal associations. Conclusion: Our study provided genetic evidence that circulating LA accounted for protective effects of n-6 PUFAs against the risk of AMD, whereas AA was responsible for deleterious effects on higher AMD risk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据