期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 106, 期 9, 页码 E3673-E3681出版社
ENDOCRINE SOC
DOI: 10.1210/clinem/dgab295
关键词
Gene-environment interaction; FTO obesity variant; exercise habit; Taiwan biobank
资金
- research grant for Front Runner of Future Diabetes Research (FFDR) from Japan foundation for applied enzymology [17F005]
- Japan Society for the Promotion of Science (JSPS) [19K19432]
- Kao healthcare science foundation
- Akaeda Medical Research Foundation
- Fuji Foundation for Protein Research
- Honjo International Scholarship Foundation
- Salt Science Research Foundation
- Japan health and research institute
- Health Care Science Institute
- grant for FFDR from Japan foundation for applied enzymology
- Sumitomo insurance welfare foundation
- Hokuto foundation for bioscience
- Japan Milk Academic Alliance
- Foundation for Dietary Scientific Research
- Taichung Veterans General Hospital [TCVGH1097316C, TCVGH-1097327D]
- JSPS
- Grants-in-Aid for Scientific Research [19K19432] Funding Source: KAKEN
The study investigates the interaction between the FTO obesity variant rs1421085 and regular exercise on changes in body weight/BMI. Results show that individuals with the risk allele of rs1421085 tend to gain more weight and increase BMI if they do not exercise, but tend to gain less weight and BMI if they exercise regularly. The beneficial effect of exercise in maintaining body weight is greater in individuals genetically prone to obesity.
Context: Gene-exercise interaction on cross-sectional body mass index (BMI) has been extensively studied and is well established. However, gene-exercise interaction on changes in body weight/BMI remains controversial. Objective: To examine the interaction between the FTO obesity variant and regular exercise on changes in body weight/BMI. Participants: Taiwan Biobank participants aged 30-70 years (N = 20 906) were examined at both baseline and follow-up visit (mean follow-up duration: 3.7 years). Main Outcome Measures: The interaction between the FTO obesity variant rs1421085 and regular exercise habit (no exercise, <= 20 metabolic equivalent of tasks (METs)/week exercise, >20 METs/week exercise) on changes in body weight/BMI. Results: Individuals with the risk allele of rs1421085 gained more weight and increased BMI than those without the risk allele if they did not exercise. In contrast, individuals with the risk allele gained less weight and BMI if they exercised regularly, indicating an interaction between rs1421085 and regular exercise habit (P = .030 for Delta body weight and P= .034 for Delta BMI).The effect of exercise on maintaining body weight was larger in those with the risk allele of rs1421085. When we focused on individuals without regular exercise at baseline, individuals with the risk allele again tended to lose more weight than those with a nonrisk allele if they had acquired an exercise habit by the follow-up visit. Conclusion: The beneficial effect of exercise is greater in individuals genetically prone to obesity due to the interaction between the FTO obesity variant rs1421085 and regular exercise on changes in body weight and BMI.
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