New Horizon: Exercise and a Focus on Tissue-Brain Crosstalk

The world population is aging, leading to increased rates of neurodegenerative disorders. Exercise has countless health benefits and has consistently been shown to improve brain health and cognitive function. The purpose of this review is to provide an overview of exercise-induced adaptations in the brain with a focus on crosstalk between peripheral tissues and the brain. We highlight recent investigations into exercise-induced circulating factors, or exerkines, including irisin, cathepsin B, GPLD1, and ketones and the mechanisms mediating their effects in the brain.

Automated summary

Exercise has been shown to improve brain health and cognitive function, with recent research focusing on how peripheral tissues communicate with the brain through circulating factors produced during exercise. This crosstalk plays a crucial role in the adaptations that occur in the brain in response to physical activity.