4.7 Article

Deciphering the Role of PGRMC1 During Human Decidualization Using an In Vitro Approach

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Summary: Preeclampsia is a dangerous complication in obstetrics that poses life-threatening risks to both mothers and infants. Shallow cytotrophoblast invasion through the uterine decidua is considered a cause of preeclampsia, but the exact reason for deficient invasion remains unknown. The deficiency in decidualization and expression of annexin A2 is associated with impaired invasion and establishment of the maternal-fetal interface. Detection of transcriptional markers related to decidualization deficiency before or after conception can help identify women at risk of developing severe preeclampsia and aid in developing therapeutic strategies to improve decidualization.

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