期刊
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
卷 46, 期 3, 页码 285-298出版社
WILEY
DOI: 10.1111/eci.12591
关键词
Cancer; high fat diet; Ketogenic diet; mitochondria; neurological diseases
资金
- Foundation for Science and Technology (FCT), Portugal
- FEDER/Compete
- [PTDC/DTP-FTO/2433/2014]
- [UID/NEU/04539/2013]
- [SFRH/BPD/109339/2015]
- [SFRH/BPD/101169/2014]
- [CENTRO-07-ST24-FEDER-002008]
- Fundação para a Ciência e a Tecnologia [UID/NEU/04539/2013] Funding Source: FCT
BackgroundThe employment of dietary strategies such as ketogenic diets, which force cells to alter their energy source, has shown efficacy in the treatment of several diseases. Ketogenic diets are composed of high fat, moderate protein and low carbohydrates, which favour mitochondrial respiration rather than glycolysis for energy metabolism. DesignThis review focuses on how oncological, neurological and mitochondrial disorders have been targeted by ketogenic diets, their metabolic effects, and the possible mechanisms of action on mitochondrial energy homeostasis. The beneficial and adverse effects of the ketogenic diets are also highlighted. Results and conclusionsAlthough the full mechanism by which ketogenic diets improve oncological and neurological conditions still remains to be elucidated, their clinical efficacy has attracted many new followers, and ketogenic diets can be a good option as a co-adjuvant therapy, depending on the situation and the extent of the disease.
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