期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 236, 期 11, 页码 7792-7800出版社
WILEY
DOI: 10.1002/jcp.30388
关键词
mechanotransduction; orthodontic tooth movement; periodontal remodeling; YAP; TAZ
资金
- National Natural Science Foundation of China [81600896]
- Science and Technology Project of Sichuan Province, China [2021YJ0150]
YAP/TAZ are crucial transcriptional coactivators involved in the mechanical-biochemical signal transduction, playing a central role in regulating cellular responses and tissue remodeling during orthodontic tooth movement.
Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators encoded by paratactic homologous genes, shuttle-crossing between cytoplasm and nucleus to regulate the gene expression and cell behavior and standing at the center place of the sophisticated regulatory networking of mechanotransduction. Orthodontic tooth movement (OTM) is a process in which extracellular mechanical stimuli are transformed into intracellular biochemical signals to regulate cellular responses and tissue remodeling. Literature studies have confirmed that YAP/TAZ plays an important role not only in embryonic development, homeostasis and tumorigenesis, but also in mechanical-biochemical signal transduction of periodontal tissues under the mediation of various signal molecules in its upstream and downstream. Herein, we review the advances in the roles and mechanisms of YAP/TAZ in OTM to provide insights for better understanding and further study of the OTM and possible targeted clinical intervention in orthodontic treatment.
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