期刊
JOURNAL OF CELL SCIENCE
卷 134, 期 9, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.249060
关键词
Actin; Atherosclerosis; Diabetes; Hypertension; Profilin
类别
资金
- National Institutes of Health [R01CA108607, R01CA248873]
- Department of Defense [W81XWH-19-1-0768]
- Cardiovascular bioengineering training program (CBTP NHLBI T32 grant) [NHLBI5T32HL076124-13]
- Cardiology training program T32 grant [NHLBIT32HL129964-05]
- National Cancer Center Fellowship
Dynamic remodeling of the actin cytoskeleton is crucial for various cellular processes, and dysregulated expression of actin-monomer-binding protein Pfn1 is implicated in cardiovascular diseases.
Dynamic remodeling of the actin cytoskeleton is an essential feature for virtually all actin-dependent cellular processes, including cell migration, cell cycle progression, chromatin remodeling and gene expression, and even the DNA damage response. An altered actin cytoskeleton is a structural hallmark associated with numerous pathologies ranging from cardiovascular diseases to immune disorders, neurological diseases and cancer. The actin cytoskeleton in cells is regulated through the orchestrated actions of a myriad of actin-binding proteins. In this Review, we provide a brief overview of the structure and functions of the actin-monomer-binding protein profilin-1 (Pfn1) and then discuss how dysregulated expression of Pfn1 contributes to diseases associated with the cardiovascular system.
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