期刊
JOURNAL OF CELL BIOLOGY
卷 220, 期 4, 页码 -出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.202102030
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资金
- National Institutes of Health [AR074988, NS044916]
The study reveals a phenomenon in which neuromuscular junction synapse elimination triggers myelination of terminal motor axon branches, with a mechanism involving synaptic activity, cytoskeletal maturation, and the transport of trophic factors.
In this issue, Wang et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.201911114) describe a phenomenon in which neuromuscular junction synapse elimination triggers myelination of terminal motor axon branches. They propose a mechanism initiated by synaptic pruning that depends on synaptic activity, cytoskeletal maturation, and the associated anterograde transport of trophic factors including Neuregulin 1-III.
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