期刊
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
卷 77, 期 6, 页码 685-698出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0000000000000990
关键词
heart failure; mineralocorticoid receptor antagonists; antagonists; aldosterone receptor; diabetes mellitus; type 2/complications; hypertension
Aldosterone plays a crucial role in cardiovascular diseases, but the use of traditional steroidal MRAs is often limited by the risk of hyperkalemia. Nonsteroidal MRAs have been developed to overcome this limitation and have the potential to reduce cardiac and renal outcomes in conditions like heart failure, hypertension, and type 2 diabetes with renal disease.
Aldosterone, a mineralocorticoid hormone, plays a role in the pathophysiology of many cardiovascular disease states. Mineralocorticoid receptor antagonists (MRAs) have been shown to improve clinical outcomes in select patient populations. However, use of available steroidal receptor antagonists, eplerenone and spironolactone, is often limited by the risk or development of hyperkalemia. Nonsteroidal MRAs have been designed to overcome this limitation. The nonsteroidal MRAs have been studied in patients with heart failure with reduced ejection fraction, hypertension, and to lower the risk of cardiac and renal outcomes in those with type 2 diabetes and renal disease. In this review, the pharmacology of the MRAs is compared, the data evaluating the use of nonsteroidal MRAs are examined, and the place of this new generation of therapy is discussed. At this time, it seems that there could be a future role for nonsteroidal MRAs to reduce the risk of renal outcomes in high-risk individuals
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据