4.5 Article

Artificially altered gravity elicits cell homeostasis imbalance in planarian worms, and cerium oxide nanoparticles counteract this effect

期刊

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 109, 期 11, 页码 2322-2333

出版社

WILEY
DOI: 10.1002/jbm.a.37215

关键词

cerium oxide nanoparticles; hypergravity; microgravity; planarians; stem cells

资金

  1. European Space Agency [CORA-GBF-2017-001]

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Gravity alterations have complex and mostly detrimental effects on biological systems, particularly through oxidative stress affecting tissue homeostasis and development. Using a simple worm model, pathogenic mechanisms and molecular responses to gravity alterations can be studied effectively.
Gravity alterations elicit complex and mostly detrimental effects on biological systems. Among these, a prominent role is occupied by oxidative stress, with consequences for tissue homeostasis and development. Studies in altered gravity are relevant for both Earth and space biomedicine, but their implementation using whole organisms is often troublesome. Here we utilize planarians, simple worm model for stem cell and regeneration biology, to characterize the pathogenic mechanisms brought by artificial gravity alterations. In particular, we provide a comprehensive evaluation of molecular responses in intact and regenerating specimens, and demonstrate a protective action from the space-apt for nanotechnological antioxidant cerium oxide nanoparticles.

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