期刊
BRAIN RESEARCH
卷 1617, 期 -, 页码 18-27出版社
ELSEVIER
DOI: 10.1016/j.brainres.2014.07.050
关键词
Neuroimmunology; Microglia; Innate and adaptive immunity; Autism spectrum disorder; Rett; Syndrome
资金
- NIH training Grant in immunology and a fellowship from the Hartwell Foundation [T32-AI007496]
- National Institutes on Aging [AG034113]
- SFARI [276315]
- RSRT
It has been known for decades that the immune system has a tremendous impact on behavior. Most work has described the negative role of immune cells on the central nervous system. However, we and others have demonstrated over the last decade that a well-regulated immune system is needed for proper brain function. Here we discuss several neuro-immune interactions, using examples from brain homeostasis and disease states. We will highlight our understanding of the consequences of malfunctioning immunity on neurodevelopment and will discuss the roles of the innate and adaptive immune system in neurodevelopment and how T cells maintain a proper innate immune balance in the brain surroundings and within its parenchyma. Also, we describe how immune imbalance impairs higher order brain functioning, possibly leading to behavioral and cognitive impairment. Lastly, we propose our hypothesis that some behavioral deficits in neurodevelopmental disorders, such as in autism spectrum disorder, are the consequence of malfunctioning immunity. This article is part of a Special Issue entitled SI: Neuroimmunology in Health And Disease. (C) 2014 Elsevier B.V. All rights reserved.
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