期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 32, 期 9, 页码 1182-1202出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2021.1909414
关键词
Biodegradable; electrospinning; nanofibrous membranes; curcumin; cyclodextrin
资金
- Indian Council of Medical Research (ICMR), New Delhi [5/3/8/3/2019-ITR]
- MHRD (Ministry of Human Resource and Development), India
The study optimized the integration of an inclusion complex of curcumin and beta-cyclodextrin into electrospun PVA nanofibers using Taguchi's design of experiments, resulting in uniform bead-free nanofibers with minimal average diameter and variation.
Hydrophilic polyvinyl alcohol (PVA) based electrospun nanofibrous mats (ENMs) are recently being used for the designing and fabrication of active wound dressing materials. Thus, in this study an inclusion complex (IC) of curcumin (CUR) and beta-cyclodextrin (beta-CD) was optimally incorporated in electrospun PVA nanofibers, to obtain uniform bead-free nanofibers with minimum average diameter and variation using Taguchi's design of experiments (DOE). The optimum level parameters were ascertained using Taguchi's methodology, to obtain IC loaded PVA based bead-free ENMs, by varying IC (similar to 20, similar to 40, and similar to 60 wt.%) loading, applied voltage, solution concentration, and N, N-dimethylformamide (DMF) content in the electrospinning solution mixture. Validation experiments revealed a good agreement between the predicted and experimental values of fiber diameter, diameter-variation, and bead-numbers. Analysis of variance (ANOVA) showed a major influence of IC loading on the average fiber diameter and the number of bead defects, for IC-loaded PVA based ENMs. However, the DMF content of the solvent mixture significantly influenced the diameter variations of ENMs. The surface morphologies of ENMs were analyzed using Scanning Electron Microscopy (SEM) whereas the microstructural aspects were studied by Wide-Angle X-ray Diffraction (WAXD) and Fourier transform infrared (FT-IR) spectroscopy. The thermal properties were characterized by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) whereas the mechanical properties were measured by using uniaxial tensile testing and dynamic mechanical analysis (DMA). The variation in properties of IC loaded PVA based ENMs were correlated with neat PVA based ENMs fabricated using a similar set of optimized electrospinning process parameters. The study conceptually demonstrated the optimal designing of structurally-engineered hydrophilic IC loaded PVA based ENMs by using the Taguchi approach based on orthogonal DOE as potential drug release substrates.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据