期刊
JOURNAL OF AVIAN BIOLOGY
卷 52, 期 5, 页码 -出版社
WILEY
DOI: 10.1111/jav.02734
关键词
bluethroat; extra-pair mating; major histocompatibility complex; optimal MHC; phytohaemagglutinin
类别
资金
- Norwegian Research Council [107585/V40, 146984/432]
- Nansen Endowment [147/98]
- Natural History Museum, University of Oslo
The study suggests that an intermediate number of MHC class II alleles may be correlated with an increased skin-swelling response to phytohaemagglutinin injections in bluethroat nestlings. Skin swelling was associated with MHCII allele count at the among-brood level, and with paternity, indicating a potential role of MHCII alleles in the PHA response and mate choice in this species.
Genes of the major histocompatibility complex (MHC) are crucial for adaptive immunity, and theory predicts that the optimal number of alleles is intermediate rather than maximal. Support for such an intermediate optimum in MHC allele count has mainly been demonstrated in studies on parasite load and reproductive traits. In this study we tested if an intermediate number of MHC class II (MHCII) alleles based on positively selected sites was correlated with an increased skin-swelling response to two consecutive injections of phytohaemagglutinin (PHA) in bluethroat Luscinia svecica nestlings. We found that nestlings that were closer to the population mean in their number of alleles had a higher response to the first injection, supporting an intermediate, optimal number of alleles. After the second PHA injection, we found that the skin swelling was associated with MHCII allele count only at the among-brood level, and with paternity (extra-pair offspring had a larger swelling than within-pair offspring). We therefore conclude that the PHA response is partly correlated with MHCII allele count, but that additional factors must be involved in both the PHA response and in female extra-pair mate choice in this species.
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