4.4 Article

Cytotoxic lanostane triterpenoids from the ethanol extract of Schisandra viridis

期刊

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 24, 期 4, 页码 321-327

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2021.1918120

关键词

Schisandraceae; Schisandra viridis; lanostane triterpenoids; cytotoxicity

资金

  1. Nantong Science and Technology Plan Guidance Project [MSZ19192]

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Three new lanostane triterpenoids were isolated from the stems of Schisandra viridis, with compound 1 showing cytotoxic activities on all six tested human lung cancer cell lines. Structural elucidation was performed using NMR spectroscopy and high resolution mass spectrometry.
Three new lanostane triterpenoids, designated as 6-hydroxyl schiglausin A (1), 29-hydroxyl schiglausin D (2), and 6-hydroxyl schiglausin G (3), were isolated from the ethanol extract of the stems of Schisandra viridis. Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (H-1-H-1 COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activities. As a result, compound 1 exhibited cytotoxic activities for all six tested human lung cancer cell lines with IC50 values less than 10 mu M.

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