期刊
BRAIN RESEARCH
卷 1624, 期 -, 页码 380-389出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2015.07.058
关键词
CTH; CSE; Hydrogen sulfide; Chronic pain; Knockout mice; Dorsal root ganglia
资金
- Deutsche Forschungsgemeinschaft [Sonderforschungsbereich 815-A07, Sonderforschungsbereich 815-A14]
- Else Kroner-Fresenius Foundation (EKFS)
- Research Training Group Translational Research Innovation - Pharma (TRIP)
- LOEWE-Zentrum Translational Medicine and Pharmacology
Accumulating lines of evidence indicate that hydrogen sulfide (H2S) contributes to the processing of chronic pain. However, the sources of H2S production in the nociceptive system are poorly understood. Here we investigated the expression of the H2S releasing enzyme cystathionine gamma-lyase (CSE) in the nociceptive system and characterized its role in chronic pain signaling using CSE deficient mice. We show that paw inflammation and peripheral nerve injury led to upregulation of CSE expression in dorsal root ganglia. However, conditional knockout mice lacking CSE in sensory neurons as well as global CSE knockout mice demonstrated normal pain behaviors in inflammatory and neuropathic pain models as compared to WT littermates. Thus, our results suggest that CSE is not critically involved in chronic pain signaling in mice and that sources different from CSE mediate the pain relevant effects of H2S. (C) 2015 Elsevier B.V. All rights reserved.
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