4.7 Article

Temporal kinetics of bovine mammary IgG secretion into colostrum and transition milk

期刊

JOURNAL OF ANIMAL SCIENCE
卷 99, 期 5, 页码 -

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/jas/skab083

关键词

calf; dairy; immunoglobulin; mammary; nutrition

资金

  1. Northeast Sustainable Agriculture Research and Education (NE-SARE) [GNE19-220-33243]
  2. Cornell CALS Charitable Trust Research fund
  3. College of Agriculture and Life Sciences, Cornell University

向作者/读者索取更多资源

Neonatal calf survival and health rely on sufficient IgG intake and passive immunity transfer. Colostrum accounts for only 25% of total IgG production, with early transition milk potentially contributing more IgG than colostrum.
Neonatal calf survival and health is predominantly dependent on sufficient consumption of immunoglobulin G (IgG) and the resulting transfer of passive immunity (TPI). In this study, we investigate the potential for continued IgG secretion and temporal kinetics of mammary IgG output in sequential milkings performed at 0, 4, 16, 28, 40, and 52 hr postcalving in Holstein dairy cows. For colostrum (0 hr), we also scrutinize the relationships between IgG concentration, volume, refractometer readings (degrees Bx values, Brix) and concentration of sugars (lactose and glucose). Mammary transcripts postpartum (0 hr) indicated that active IgG secretion continues beyond the first milking (colostrum; n = 4 to 5). IgG measurements at the different timepoints indicated that colostrum represents only 25.1% of the total IgG produced across the 6 sequential milking timepoints, with a substantial 48.9% being secreted into transition milk over the next 3 timepoints (4-, 6-, and 28-hr) combined. The differences on the basis of IgG concentrations across 0-, 4-, and 16-hr milking timepoints were not statistically significant (P = 0.1522; n = 9). For colostrum, volume remained highly variable, even with induced let-down prior to milking (n = 27). Nonetheless, colostrum IgG secretion was significantly co-regulated with volume (R-2 = 0.915; P < 0.001; n = 18), an association that was stronger than that measured for lactose (R-2 = 0.803; P < 0.001; n = 18) and glucose (R-2 = 0.467; P = 0.002; n = 17). Comparing colostrum degrees Bx values to absolute IgG concentrations showed no correlation (R-2 = 0.127; P = 0.07; n = 27); biochemical separation of colostrum components indicated that both proteins and nonprotein solutes could affect degrees Bx values (P < 0.0001 for both; n = 5). This suggests that degrees Bx values do not reasonably indicate IgG concentration to serve as a measure of colostrum quality. Additionally, our finding that early transition milk (4-, 6-, and 28-hr) can contribute substantially more IgG than colostrum forces a rethink of existing feeding paradigms and means to maximize TPI in calves. Collectively, our results reveal the remarkable value of early transition milk and caveats to colostrum assessments that could advance application in enhancing neonatal calf health.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据