期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 82, 期 1, 页码 249-260出版社
IOS PRESS
DOI: 10.3233/JAD-210232
关键词
Amygdala; amyloid-beta; APOE; depression; depressive symptoms; entorhinal; PET imaging; tau
资金
- National Institutes of Health [N01-HC-25195, HHSN268201500001I, 75N92019D00031]
- National Institute on Aging [AG059421, AG054076, AG049607, AG033090, AG066524, NS017950]
- American Academy of Neurology Career Development Award
The study found that while depressive symptoms and depression were not associated with PET outcomes in the overall sample, there was a significant cross-sectional association between depressive symptoms and increased tau PET uptake in the entorhinal cortex and amygdala among APOE ε4 allele carriers.
Background: Depressive symptoms predict increased risk for dementia decades before the emergence of cognitive symptoms. Studies in older adults provide preliminary evidence for an association between depressive symptoms and amyloid-beta (A beta) and tau accumulation. It is unknown if similar alterations are observed in midlife when preventive strategies may be most effective. Objective: The study aim was to evaluate the association between depressive symptoms and cerebral A beta and tau in a predominately middle-aged cohort with examination of the apolipoprotein (APOE) epsilon 4 allele as a moderator. Methods: Participants included 201 adults (mean age 53 +/- 8 years) who underwent C-11-Pittsburgh Compound B amyloid and F-18-Flortaucipir tau positron emission tomography (PET) imaging. Depressive symptoms were evaluated with the Center for Epidemiological Studies Depression Scale (CES-D) at the time of PET imaging, as well as eight years prior. Associations between depressive symptoms at both timepoints, as well as depression (CES-D >= 16), with regional A beta and tau PET retention were evaluated with linear regression adjusting for age and sex. Interactions with the APOE epsilon 4 allele were explored. Results: Depressive symptoms and depression were not associated with PET outcomes in the overall sample. However, among APOE epsilon 4 allele carriers, there was a significant cross-sectional association between depressive symptoms and increased tau PET uptake in the entorhinal cortex (beta = 0.446, SE = 0.155, p = 0.006) and amygdala (beta = 0.350, SE = 0.133, p = 0.012). Conclusion: Although longitudinal studies are necessary, the results suggest that APOE epsilon 4 carriers with depressive symptoms may present with higher susceptibility to early tau accumulation in regions integral to affective regulation and memory consolidation.
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