期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 69, 期 12, 页码 3585-3600出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c00751
关键词
polyphenols; nonalcoholic fatty liver disease (NAFLD); gut-brain-liver axis; gut microbiota; gut metabolites; hormones; mechanisms
资金
- National Natural Science Foundation of China [31771978]
- Six Talent Peaks Project in Jiangsu Province [NY-095]
- National First-class Discipline Program of Food Science and Technology [JUFSTR20180201]
- Innovation and Exploration Fund of State Key Laboratory of Food Science and Technology, Jiangnan University [SKLF-ZZB-201904]
- Fundamental Research Funds for the Central Universities [JUSRP21802]
This review discusses the role of dietary polyphenols in improving NAFLD by regulating the intestinal microecology. Polyphenols can control NAFLD through gut-brain-liver cross-talk, affecting microbial community structure, gut metabolites, and gut-derived hormones. Understanding the communication among the intestine, brain, and liver provides new insights into the mechanisms of dietary polyphenols in NAFLD pathology.
Polyphenols are a group of micronutrients widely existing in plant foods including fruits, vegetables, and teas that can improve nonalcoholic fatty liver disease (NAFLD). In this review, the existing knowledge of dietary polyphenols for the development of NAFLD regulated by intestinal microecology is discussed. Polyphenols can influence the vagal afferent pathway in the central and enteric nervous system to control NAFLD via gut-brain-liver cross-talk. The possible mechanisms involve in the alteration of microbial community structure, effects of gut metabolites (short-chain fatty acids (SCFAs), bile acids (BAs), endogenous ethanol (EnEth)), and stimulation of gut-derived hormones (ghrelin, cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), and leptin) based on the targets excavated from the gut-brain-liver axis. Consequently, the communication among the intestine, brain, and liver paves the way for new approaches to understand the underlying roles and mechanisms of dietary polyphenols in NAFLD pathology.
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