期刊
JAPANESE JOURNAL OF APPLIED PHYSICS
卷 60, 期 SD, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.35848/1347-4065/abf2ab
关键词
contrast agents; indocyanine green derivative; phospholipid; attenuation; viscoelasticity; stability
资金
- JSPS KAKENHI [JP17K11529, JP19H04436]
- JSPS Core-to-Core Program
- Termo Foundation for Life Sciences and Arts
- Institute for Global Prominent Research at Chiba University
- Tenure Track program at Chiba University
The lipid-coated microbubbles with an indocyanine green derivative demonstrated significant influence on NIR fluorescence intensity, stability, and viscoelastic properties, while the effect on contrast agent used for ultrasound imaging was minimal. The performance of this contrast agent for dual ultrasound and NIR fluorescence imaging showed a significant trade-off relationship with lipid composition.
Lipid-coated microbubbles (MBs) with an indocyanine green (ICG) derivative were fabricated for ultrasound and near-infrared (NIR) fluorescence dual imaging. We characterized the NIR-fluorescence intensity, stability and viscoelastic properties of the encapsulating lipid shell, focusing on the influence of the ICG derivative and lipid compositions. In terms of the NIR fluorescence intensity, the fluorescence intensity of the MBs (with the ICG derivative) was significantly affected by the lipid composition of the MB shell. Regarding the contrast agent used for ultrasound imaging, the stability of the MBs and viscoelastic properties of shell also depended on the lipid compositions, while the incorporation of the ICG derivative into the MB shells had a negligible effect. The performance of this contrast agent for ultrasound and NIR fluorescence dual-imaging exhibited a significant trade-off relationship for the lipid composition.
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