期刊
INTERNATIONAL MICROBIOLOGY
卷 24, 期 4, 页码 531-543出版社
SPRINGER
DOI: 10.1007/s10123-021-00183-z
关键词
Yeast cell wall; CWI pathway; Slt2; MAPK; Stress response; Phosphorylation
资金
- Ministerio de Ciencia, Innovacion y Universidades (Spain) [PID2019-105342 GB-I00]
- Comunidad de Madrid (Spain) [S2017/BMD-3691]
- European Structural and Investment Funds
Mitogen-activated protein kinases (MAPKs) are signaling proteins involved in regulating most eukaryotic cellular processes, with Slt2 being a fundamental element of the cell wall integrity pathway in Saccharomyces cerevisiae. Slt2, like other MAPKs, has typical structural traits of eukaryotic protein kinases along with conserved domains allowing precise spatio-temporal regulation of its activity.
Mitogen-activated protein kinases (MAPKs) are evolutionarily conserved signaling proteins involved in the regulation of most eukaryotic cellular processes. They are downstream components of essential signal transduction pathways activated by the external stimuli, in which the signal is conveyed through phosphorylation cascades. The excellent genetic and biochemical tractability of simple eukaryotes such as Saccharomyces cerevisiae has significantly contributed to gain fundamental information into the physiology of these key proteins. The budding yeast MAPK Slt2 was identified 30 years ago and was later revealed as a fundamental element of the cell wall integrity (CWI) pathway, one of the five MAPK routes of S. cerevisiae. As occurs with other MAPKs, whereas Slt2 displays the core typical structural traits of eukaryotic protein kinases, it also features conserved domains among MAPKs that allow an exquisite spatio-temporal regulation of their activity and binding to activating kinases, downregulatory phosphatases, or nuclear transcription factors. Additionally, Slt2 bears a regulatory extra C-terminal tail unique among S. cerevisiae MAPKs. Here, we review the structural and functional basis for the signaling role of Slt2 in the context of the molecular architecture of this important family of protein kinases.
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