期刊
BRAIN RESEARCH
卷 1617, 期 -, 页码 47-62出版社
ELSEVIER
DOI: 10.1016/j.brainres.2014.04.004
关键词
Microbiota; Immunoregulation; Co-evolution; Old Friends; Hygiene; Depression
资金
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- National Center for Complementary and Alternative Medicine [R01AT004698, R01AT004698-01A1S1]
- Depressive and Bipolar Disorder Alternative Treatment Foundation
- Brain and Behavior Research Foundation
- Pamlab
- Lilly
- North American Center for Continuing Education
- CME Incite
- National Institute of Mental Health [R01MH065702, R01DA019921]
- National Science Foundation [NSF-IOS 0921969]
- NARSAD, Brain & Behavior Research Foundation Young Investigator Award
The immune system influences brain development and function. Hygiene and other early childhood influences impact the subsequent function of the immune system during adulthood, with consequences for vulnerability to neurodevelopmental and psychiatric disorders. Inflammatory events during pregnancy can act directly to cause developmental problems in the central nervous system (CNS) that have been implicated in schizophrenia and autism. The immune system also acts indirectly by farming the intestinal microbiota, which then influences brain development and function via the multiple pathways that constitute the gut brain axis. The gut microbiota also regulates the immune system. Regulation of the immune system is crucial because inflammatory states in pregnancy need to be limited, and throughout life inflammation needs to be terminated completely when not required; for example, persistently raised levels of background inflammation during adulthood (in the presence or absence of a clinically apparent inflammatory stimulus) correlate with an increased risk of depression. A number of factors in the perinatal period, notably immigration from rural low-income to rich developed settings, caesarean delivery, breastfeeding and antibiotic abuse have profound effects on the microbiota and on immunoregulation during early life that persist into adulthood. Many aspects of the modem western environment deprive the infant of the immunoregulatory organisms with which humans co-evolved, while encouraging exposure to non-immunoregulatory organisms, associated with more recently evolved crowd infections. Finally, there are complex interactions between perinatal psychosocial stressors, the microbiota, and the immune system that have significant additional effects on both physical and psychiatric wellbeing in subsequent adulthood. This article is part of a Special Issue entitled Neuroimmunology in Health And Disease. (C) 2014 The Authors. Published by Elsevier B.V.
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