期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 600, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120476
关键词
Skin adhesive system; Bacterial cellulose nanofibers; Cell-penetrating peptide; Water retention
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [NRF-2019R1A2C1086383]
BCNFs modified with CPP can enhance skin adhesion under wet conditions, showing both hydrophobic and electrostatic interactions with the cell membrane. This tailored skin attraction plays a key role in improving skin water retention.
Bacterial cellulose nanofibrils (BCNFs), possessing excellent biocompatibility as well as hygroscopicity, are receiving high interest as a biomaterial for biomedical and healthcare treatments, since they exert various interactions with tissues after surface modification with biochemicals such as peptides, proteins, and catechols. Herein, we report a BCNF-based skin adhesion system, wherein cell penetrating peptide (CPP)-conjugated BCNFs were employed to enhance the attraction to the skin under wet conditions. For this, we conjugated Bac7, a type of CPP, with the carboxylate of 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized BCNFs. We showed that Bac7-conjugated BCNFs exhibited both hydrophobic and electrostatic interactions with the cell membrane, which eventually led to the remarkable adhesion against the skin surface. Furthermore, we demonstrated that such tailored skin attraction played a key role in improving skin water retention.
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