期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 600, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120484
关键词
Cell penetrating peptides; Corneal diseases; Fungal keratitis; Fusarium sp; Tat(2)natamycin
资金
- Nanomission, Department of Science and Technology (DST), Government of India [SR/NM/NS-1477/2014]
- Indian Institute of Technology, Delhi
Tat(2)natamycin, a conjugate with cell penetrating peptides (CPPs), demonstrates enhanced ocular penetration and antifungal efficacy compared to natamycin alone in treating fungal keratitis.
Natamycin is the only FDA approved drug that is used as a first line of treatment for fungal keratitis caused by filamentous fungi, however natamycin is known for poor corneal penetration. Cell penetrating peptides (CPPs) are emerging nanocarriers for the enhanced delivery of various macromolecules owing to their distinct cellular translocation ability. In the present study, tissue penetration ability and antifungal efficacy of CPP (Tat(2)) conjugated natamycin has been investigated and compared with natamycin alone in vivo. Results show that Tat(2)natamycin exhibits five- fold higher ocular penetration than natamycin alone when given topically. Complete resolution of fungal keratitis in 44% of the animals in Tat2natamycin treated group as compared to only 13% of the animals in natamycin treated group further highlights its increased antifungal efficacy. Hence, this conjugate is a promising antifungal molecule with enhanced ocular penetration as well as antifungal efficacy against selected fungal species.
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