期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 601, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120498
关键词
-
资金
- Research and Researchers for Industries (RRi) from the Thailand Research Fund [PHD59I0031]
- Chulalongkorn University
- Capsule Products Co., Ltd
- Ratchadaphiseksomphot Endowment Fund
Composite films composed of zein and methacrylic acid copolymer were studied to understand their miscibility and the effects of composition and plasticizers. Techniques such as DSC, FTIR, and Raman spectroscopy were used to analyze the molecular level miscibility and phase behavior of the polymer blends. The results showed that polyethylene glycol 1000 had a more significant plasticization effect, increasing the beta-sheets content in the film.
Composite films have gained interest for producing films with optimal properties, without the need of chemical modification. Miscibility of components in the film is important for attaining reproducible and consistent film properties. This study used several techniques, i.e. differential scanning calorimetry, Fourier transform infrared spectroscopy and Raman spectroscopy to understand the degree of miscibility of components and its impact on morphology and mechanical properties of the composite film prepared by casting the blend of zein and methacrylic acid copolymer (Eudragit (R) L100-55). The effects of composition and plasticization by triethyl citrate and polyethylene glycol 1000 were explored. The results demonstrate the miscibility of zein and methacrylic acid copolymer at a molecular level; and the phase behavior of polymer blends is modified by plasticization. Polyethylene glycol 1000 is more compatible with the polymer blend. Its plasticization effect is associated with an increase in beta-sheets. Understanding the miscibility between the plasticizer and the polymer blend allows the ability to predict and control mechanical properties of the zein/methacrylic acid copolymer composite film, in particular when the plasticizer level is changed.
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