期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms22094603
关键词
ABCA7; Alzheimer’ s disease; phagocytosis; cholesterol; Aβ peptides
资金
- Region Hauts-de-France
- University of Artois
- foundation France Alzheimer et Maladies apparentees (AAP 2013) [22]
- ERANET JPcofuND 2-NET-PETABC collaborative project from the French national agency (ANR) [ANR-20-JPW2-0002-04]
- Deutsche Forschungsgemeinschaft/Germany [DFG 263024513]
- Ministerium fur Wirtschaft und Wissenschaft Sachsen-Anhalt/Germany [ZS/2016/05/78617]
- Latvian Council of Science/Latvia [lzp-2018/1-0275]
- Nasjonalforeningen [16154]
- HelseSO/Norway [2019054, 2019055]
- Barnekreftforeningen [19008]
- EEA grant/Norges grants [TAC. R TARIMAD TO100078]
- Norges forskningsradet/Norway [260786 PROP-AD, 295910 NAPI, 327571 PETABC]
- JPND
- AKA - Finland [301228]
- BMBF - Germany [01ED1605]
- CSO-MOH - Israel [30000-12631]
- NFR - Norway [260786]
- FFG - Austria [882717]
- MSMT - Czech Republic [8F21002]
- VIAA - Latvia [ES RTD/2020/26]
- ANR - France [20-JPW2-0002-04]
- SRC - Sweden [2020-02905, 2015-06795]
- European Union [643417]
- University of Artois [BQR-ABCA7]
- BMBF - Germany
- Swedish Research Council [2020-02905] Funding Source: Swedish Research Council
- Agence Nationale de la Recherche (ANR) [ANR-20-JPW2-0002] Funding Source: Agence Nationale de la Recherche (ANR)
ABCA7 plays a central role in Alzheimer's disease by regulating molecular processes such as cholesterol metabolism and amyloid processing, impacting the onset and development of late onset Alzheimer disease. Its functions are implicated in brain functioning and disease progression.
Several studies, including genome wide association studies (GWAS), have strongly suggested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer's disease (AD). This ABC transporter is now considered as an important genetic determinant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.
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