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The miR-17-92 Cluster is Over Expressed in and Has an Oncogenic Effect on Renal Cell Carcinoma
Tsz-fung F. Chow et al.
JOURNAL OF UROLOGY (2010)
Drosophila von Hippel-Lindau Tumor Suppressor Gene Function in Epithelial Tubule Morphogenesis
Anita Hsouna et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Interaction between RasV12 and scribbled clones induces tumour growth and invasion
Ming Wu et al.
NATURE (2010)
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
Johanna C. Scheuermann et al.
NATURE (2010)
The genetic basis of kidney cancer: a metabolic disease
W. Marston Linehan et al.
NATURE REVIEWS UROLOGY (2010)
Epidemiology and risk factors for kidney cancer
Wong-Ho Chow et al.
NATURE REVIEWS UROLOGY (2010)
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
G. L. Semenza
ONCOGENE (2010)
Drosophila as a tool for personalized medicine: a primer
Yumi Kasai et al.
PERSONALIZED MEDICINE (2010)
Heterogeneity of the Tumor Vasculature
Janice A. Nagy et al.
SEMINARS IN THROMBOSIS AND HEMOSTASIS (2010)
Polycystic Kidney Disease
Peter C. Harris et al.
ANNUAL REVIEW OF MEDICINE (2009)
Smac mimetics as new cancer therapeutics
Derrick J. Chen et al.
ANTI-CANCER DRUGS (2009)
Correcting developmental errors by apoptosis: lessons from Drosophila JNK signaling
Tatsushi Igaki
APOPTOSIS (2009)
Complexity of Tumor Vasculature in Clear Cell Renal Cell Carcinoma
Chao-Nan Qian et al.
CANCER (2009)
Renal Cystic Diseases and Renal Neoplasms: A Mini-Review
Stephen M. Bonsib
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia
Nathan T. Mortimer et al.
DEVELOPMENTAL BIOLOGY (2009)
Oxidation promotes insertion of the CLIC1 chloride intracellular channel into the membrane
Sophia C. Goodchild et al.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2009)
Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks
Xuewen Song et al.
HUMAN MOLECULAR GENETICS (2009)
Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays
Meng Chen et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1
Gianfranco Distefano et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma
Renee D. Read et al.
PLOS GENETICS (2009)
Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells
Mei-Jen Chuang et al.
CANCER SCIENCE (2008)
Temsirolimus, an inhibitor of mammalian target of rapamycin
Brian I. Rini
CLINICAL CANCER RESEARCH (2008)
Prognostic factors and selection for clinical studies of patients with kidney cancer
John S. Lam et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2008)
Cell autonomy of HIF effects in Drosophila:: Tracheal cells sense hypoxia and induce terminal branch sprouting
Lazaro Centanin et al.
DEVELOPMENTAL CELL (2008)
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation
Ian J. Frew et al.
EMBO JOURNAL (2008)
A tumor necrosis factor-α-mediated pathway promoting autosomal dominant polycystic kidney disease
Xiaogang Li et al.
NATURE MEDICINE (2008)
Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value
Carsten Kempkensteffen et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2008)
Programmed cell death of primordial germ cells in Drosophila is regulated by p53 and the Outsiders monocarboxylate transporter
Yukiko Yamada et al.
DEVELOPMENT (2008)
High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma
T. Yoshimoto et al.
JOURNAL OF PATHOLOGY (2007)
Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression
Jarred Chicoine et al.
DEVELOPMENTAL CELL (2007)
HEF1-Dependent aurora a activation induces disassembly of the primary cilium
Elena N. Pugacheva et al.
CELL (2007)
von Hippel-Lindau: A tumor suppressor links Microtubules to ciliogenesis and cancer development
E. Wolfgang Kuehn et al.
CANCER RESEARCH (2007)
Role of primary cilia in the pathogenesis of polycystic kidney disease
Bradley K. Yoder
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)
Assessment of the kidney tumor vascular supply by two-phase MDCT-angiography
Jiri Ferda et al.
EUROPEAN JOURNAL OF RADIOLOGY (2007)
Involvement of hypoxia-inducible transcription factors in polycystic kidney disease
Wanja Michael Bernhardt et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy
R. Houston Thompson et al.
CLINICAL CANCER RESEARCH (2007)
Everolimus retards cyst growth and preserves kidney function in a rodent model for polycystic kidney disease
Ming Wu et al.
KIDNEY & BLOOD PRESSURE RESEARCH (2007)
Evidence of angiogenesis and microvascular regression in autosomal-dominant polycystic kidney disease kidneys: A corrosion cast study
W. Wei et al.
KIDNEY INTERNATIONAL (2006)
Polycystin-2 immunolocalization and function in zebrafish
Tomoko Obara et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein
Miguel A. Esteban et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila
Tatsushi Igaki et al.
CURRENT BIOLOGY (2006)
Melatonin as antioxidant, geroprotector and anticarcinogen
Vladimir N. Anisimov et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2006)
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease
JM Shillingford et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease
VH Haase
KIDNEY INTERNATIONAL (2006)
Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD)
PR Wahl et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2006)
Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells
Tamio Yamaguchi et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Renal-cell carcinoma
HT Cohen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis
AG Kramer-Zucker et al.
DEVELOPMENT (2005)
Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance
Y Mizutani et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease
YX Tao et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)
Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes
L Mohrmann et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition
DR Littler et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype
T Yamaguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Strict regulation of CAIXG250/MN by HIF-1α in clear cell renal cell carcinoma
K Grabmaier et al.
ONCOGENE (2004)
The human protein Hugl-1 substitutes for Drosophila Lethal giant larvae tumour suppressor function in vivo
D Grifoni et al.
ONCOGENE (2004)
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
DC Fingar et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Disturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomas
Y Yan et al.
BRITISH JOURNAL OF CANCER (2004)
Function-informed transcriptome analysis of Drosophila renal tubule
J Wang et al.
GENOME BIOLOGY (2004)
Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development
V Dammai et al.
GENES & DEVELOPMENT (2003)
A genetic screen in Drosophila for metastatic behavior
RA Pagliarini et al.
SCIENCE (2003)
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
AM Brumby et al.
EMBO JOURNAL (2003)
Measurement of renal tumour and normal tissue perfusion using positron emission tomography in a phase II clinical trial of razoxane
H Anderson et al.
BRITISH JOURNAL OF CANCER (2003)
Mitochondrial intermembrane proteins in cell death
M van Gurp et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
The genetic basis of cancer of the kidney
WM Linehan et al.
JOURNAL OF UROLOGY (2003)
Branching morphogenesis of the Drosophila tracheal system
A Ghabrial et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2003)
The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
BK Yoder et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2002)
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
CC Hudson et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling
H Kanda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Analysis of kidney tumors by comparative genomic hybridization and conventional cytogenetics
MA Rigola et al.
CANCER GENETICS AND CYTOGENETICS (2002)
Evolution of TNF signaling mechanisms:: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily
E Moreno et al.
CURRENT BIOLOGY (2002)
Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract
XL Shao et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2002)
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway
T Igaki et al.
EMBO JOURNAL (2002)
Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease
GJ Pazour et al.
CURRENT BIOLOGY (2002)
HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron
SJ Mandriota et al.
CANCER CELL (2002)
Interleukin-6, tumour necrosis factor α and interleukin-1β in patients with renal cell carcinoma
N Yoshida et al.
BRITISH JOURNAL OF CANCER (2002)
The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance
GJ Pazour et al.
JOURNAL OF CELL BIOLOGY (2002)
Developmental control of blood cell migration by the Drosophila VEGF pathway
NK Cho et al.
CELL (2002)
Homophila: human disease gene cognates in Drosophila
S Chien et al.
NUCLEIC ACIDS RESEARCH (2002)
c-Myc regulates mammalian body size by controlling cell number but not cell size
A Trumpp et al.
NATURE (2001)
Angiogenesis in autosomal-dominant polycystic kidney disease
E Bello-Reuss et al.
KIDNEY INTERNATIONAL (2001)
Melatonin increases both life span and tumor incidence in female CBA mice
VN Anisimov et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2001)
Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1
S Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
SM Srinivasula et al.
NATURE (2001)
Genomic imbalances in 61 renal cancers from the proximal tubulus detected by comparative genomic hybridization
D Reutzel et al.
CYTOGENETICS AND CELL GENETICS (2001)
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway
SM Srinivasula et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
HB Zhang et al.
GENES & DEVELOPMENT (2000)
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
S Oldham et al.
GENES & DEVELOPMENT (2000)
Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila
B Adryan et al.
ONCOGENE (2000)
Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways
XS Gao et al.
DEVELOPMENTAL BIOLOGY (2000)