Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers

The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women.

Automated summary

Maternal obesity can lead to impaired leptin signaling, resulting in high levels of estrogen and leptin in the bloodstream, which adversely affects ovarian function. This review highlights the potential impact of impaired leptin signaling on folliculogenesis and oocyte developmental competence in both mice and women.