期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms22094351
关键词
regulatory light chains; myosin regulatory light chain 2; RLC phosphorylation; cardiogenesis; cardiac muscle contractility
资金
- Singapore Ministry of Education Academic Research Funds [MOE2016-T2-1-106, 2018-T1001-030]
- Nanyang Technological University
RLCs play a critical role in cardiac function, with phosphorylation levels affecting muscle contraction force significantly. While their role in cardiac development and disease is gradually being understood, the mechanisms triggering changes in RLC phosphorylation levels remain unclear.
The role of regulatory light chains (RLCs) in cardiac muscle function has been elucidated progressively over the past decade. The RLCs are among the earliest expressed markers during cardiogenesis and persist through adulthood. Failing hearts have shown reduced RLC phosphorylation levels and that restoring baseline levels of RLC phosphorylation is necessary for generating optimal force of muscle contraction. The signalling mechanisms triggering changes in RLC phosphorylation levels during disease progression remain elusive. Uncovering this information may provide insights for better management of heart failure patients. Given the cardiac chamber-specific expression of RLC isoforms, ventricular RLCs have facilitated the identification of mature ventricular cardiomyocytes, opening up possibilities of regenerative medicine. This review consolidates the standing of RLCs in cardiac development and disease and highlights knowledge gaps and potential therapeutic advancements in targeting RLCs.
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