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SCIENTIFIC REPORTS (2021)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
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CELL METABOLISM (2020)
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DIABETOLOGIA (2020)
Inadequate beta-cell mass is essential for the pathogenesis of type 2 diabetes
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LANCET DIABETES & ENDOCRINOLOGY (2020)
Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells
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PLOS ONE (2020)
Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Immune-evasive human islet-like organoids ameliorate diabetes
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NATURE (2020)
Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation
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CELL REPORTS (2020)
Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes
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CELL REPORTS (2020)
Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes
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NATURE METABOLISM (2020)
Molecular imaging of β-cells: diabetes and beyond
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ADVANCED DRUG DELIVERY REVIEWS (2019)
Optimizing Temperature and Oxygen Supports Long-term Culture of Human Islets
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TRANSPLANTATION (2019)
Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells
Gopika G. Nair et al.
NATURE CELL BIOLOGY (2019)
Charting cellular identity during human in vitro β-cell differentiation
Adrian Veres et al.
NATURE (2019)
Myc Is Required for Adaptive β-Cell Replication in Young Mice but Is Not Sufficient in One-Year-Old Mice Fed With a High-Fat Diet
Carolina Rosselot et al.
DIABETES (2019)
Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes
Abu Saleh Md Moin et al.
CURRENT DIABETES REPORTS (2019)
Mimicking nature-made beta cells: recent advances towards stem cell-derived islets
Daniel M. Tremmel et al.
CURRENT OPINION IN ORGAN TRANSPLANTATION (2019)
Review of Advanced Hydrogel-Based Cell Encapsulation Systems for Insulin Delivery in Type 1 Diabetes Mellitus
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PHARMACEUTICS (2019)
Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells
Peng Wang et al.
CELL METABOLISM (2019)
Pancreatic Progenitors: There and Back Again
Juan Dominguez-Bendala et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)
Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells
Leonardo Velazco-Cruz et al.
STEM CELL REPORTS (2019)
Extracellular Matrix-Associated Factors Play Critical Roles in Regulating Pancreatic β-Cell Proliferation and Survival
Shannon E. Townsend et al.
ENDOCRINOLOGY (2019)
Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes
Cristina Aguayo-Mazzucato et al.
CELL METABOLISM (2018)
Replication confers β cell immaturity
Sapna Puri et al.
NATURE COMMUNICATIONS (2018)
Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential
Cindy J. M. Loomans et al.
STEM CELL REPORTS (2018)
Increasing beta cell mass to treat diabetes mellitus
Shakila Sabir et al.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2018)
Rebuilding a better home for transplanted islets
Daniel M. Tremmel et al.
ORGANOGENESIS (2018)
Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells
Anissa Gamble et al.
PLOS ONE (2018)
Solid-organ Transplants From Living Donors: Cumulative United States Experience on 140,156 Living Donor Transplants Over 28 Years
R. W. G. Gruessner et al.
TRANSPLANTATION PROCEEDINGS (2018)
CC-401 Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition
Yassan Abdolazimi et al.
ENDOCRINOLOGY (2018)
Human multipotent adult progenitor cells enhance islet function and revascularisation when co-transplanted as a composite pellet in a mouse model of diabetes
Joao Paulo M. C. M. Cunha et al.
DIABETOLOGIA (2017)
Clinical pancreatic islet transplantation
A. M. James Shapiro et al.
NATURE REVIEWS ENDOCRINOLOGY (2017)
ROCKII inhibition promotes the maturation of human pancreatic beta-like cells
Zaniar Ghazizadeh et al.
NATURE COMMUNICATIONS (2017)
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas
Huan Wang et al.
NATURE COMMUNICATIONS (2017)
Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant
Gaetano Faleo et al.
STEM CELL REPORTS (2017)
Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas
Sophie Tritschler et al.
MOLECULAR METABOLISM (2017)
Neonatal pancreatic pericytes support β-cell proliferation
Alona Epshtein et al.
MOLECULAR METABOLISM (2017)
Signals in the pancreatic islet microenvironment influence -cell proliferation
Kristie I. Aamodt et al.
DIABETES OBESITY & METABOLISM (2017)
A CCR2+ myeloid cell niche required for pancreatic β cell growth
Kristin Mussar et al.
JCI INSIGHT (2017)
Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets
Talitha van der Meulen et al.
CELL METABOLISM (2017)
Pancreatic beta-cell imaging in humans: fiction or option?
D. Laurent et al.
DIABETES OBESITY & METABOLISM (2016)
Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration
Kristie I. Aamodt et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2016)
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function
H. Efsun Arda et al.
CELL METABOLISM (2016)
Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas
Yue J. Wang et al.
CELL METABOLISM (2016)
RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes
Yurong Xin et al.
CELL METABOLISM (2016)
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
Asa Segerstolpe et al.
CELL METABOLISM (2016)
Inhibition of DYRK1A Stimulates Human β-Cell Proliferation
Ercument Dirice et al.
DIABETES (2016)
Single-Cell Transcriptomics of the Human Endocrine Pancreas
Yue J. Wang et al.
DIABETES (2016)
β-Cell adaptation in pregnancy
L. Baeyens et al.
DIABETES OBESITY & METABOLISM (2016)
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
Francesca Cinti et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)
Identification of proliferative and mature β-cells in the islets of Langerhans
Erik Bader et al.
NATURE (2016)
A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure
Maayan Baron et al.
CELL SYSTEMS (2016)
Loss of beta-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits
H. Siebe Spijker et al.
DIABETES (2015)
Human β-Cell Proliferation and Intracellular Signaling: Part 3
Andrew F. Stewart et al.
DIABETES (2015)
Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro
Holger A. Russ et al.
EMBO JOURNAL (2015)
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
Peng Wang et al.
NATURE MEDICINE (2015)
Inhibition of DYRK1A and GSK3B induces human β-cell proliferation
Weijun Shen et al.
NATURE COMMUNICATIONS (2015)
Prolactin Receptors and Placental Lactogen Drive Male Mouse Pancreatic Islets to Pregnancy-Related mRNA Changes
Lotte Goyvaerts et al.
PLOS ONE (2015)
Generation of Functional Human Pancreatic β Cells In Vitro
Felicia W. Pagliuca et al.
CELL (2014)
Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration
Marcela Brissova et al.
CELL METABOLISM (2014)
Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy
Zhiyu Wang et al.
CELL METABOLISM (2014)
Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program
Tao Gao et al.
CELL METABOLISM (2014)
Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map
Ernesto Bernal-Mizrachi et al.
DIABETES (2014)
Making surrogate β-cells from mesenchymal stromal cells: Perspectives and future endeavors
Ramesh R. Bhonde et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)
Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers
Simona Chera et al.
NATURE (2014)
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
Alireza Rezania et al.
NATURE BIOTECHNOLOGY (2014)
Pancreatic β-Cell Proliferation in Obesity
Amelia K. Linnemann et al.
ADVANCES IN NUTRITION (2014)
β1 integrin is a crucial regulator of pancreatic β-cell expansion
Giuseppe R. Diaferia et al.
DEVELOPMENT (2013)
Human Pancreatic β-Cell G1/S Molecule Cell Cycle Atlas
Nathalie M. Fiaschi-Taesch et al.
DIABETES (2013)
Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human 13-Cell Replication A Revised Model of Human β-Cell G1/S Control
Nathalie M. Fiaschi-Taesch et al.
DIABETES (2013)
Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication
Seth J. Salpeter et al.
DIABETES (2013)
beta-Cell Mass and Turnover in Humans Effects of obesity and aging
Yoshifumi Saisho et al.
DIABETES CARE (2013)
Expression of Mesenchymal and α-Cell PhenotypicMarkers in Islet β-Cells in Recently Diagnosed Diabetes
Michael G. White et al.
DIABETES CARE (2013)
Neurogenin3 Activation Is Not Sufficient to Direct Duct-to-Beta Cell Transdifferentiation in the Adult Pancreas
Xiangwei Xiao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas
M. Van de Casteele et al.
CELL DEATH & DISEASE (2013)
Liver-Derived Systemic Factors Drive β Cell Hyperplasia in Insulin-Resistant States
Abdelfattah El Ouaamari et al.
CELL REPORTS (2013)
The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells
Monica Courtney et al.
PLOS GENETICS (2013)
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
Chutima Talchai et al.
CELL (2012)
A VGF-Derived Peptide Attenuates Development of Type 2 Diabetes via Enhancement of Islet β-Cell Survival and Function
Samuel B. Stephens et al.
CELL METABOLISM (2012)
Human β-cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map
Rohit N. Kulkarni et al.
DIABETES (2012)
Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life
Brigid E. Gregg et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)
Urocortin 3 Marks Mature Human Primary and Embryonic Stem Cell-Derived Pancreatic Alpha and Beta Cells
Talitha van der Meulen et al.
PLOS ONE (2012)
The Antidiabetic Effect of Mesenchymal Stem Cells Is Unrelated to Their Transdifferentiation Potential But to Their Capability to Restore Th1/Th2 Balance and to Modify the Pancreatic Microenvironment
Fernando Ezquer et al.
STEM CELLS (2012)
Transplanted Human Bone Marrow Progenitor Subtypes Stimulate Endogenous Islet Regeneration and Revascularization
Gillian I. Bell et al.
STEM CELLS AND DEVELOPMENT (2012)
Elutriated Stem Cells Derived from the Adult Bone Marrow Differentiate into Insulin-Producing Cells In Vivo and Reverse Chemical Diabetes
Svetlana Iskovich et al.
STEM CELLS AND DEVELOPMENT (2012)
Long-Term (5 Years) Efficacy and Safety of Pancreas Transplantation Alone in Type 1 Diabetic Patients
Ugo Boggi et al.
TRANSPLANTATION (2012)
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
Janel L. Kopp et al.
DEVELOPMENT (2011)
Historical Perspective: Beginnings of the β-Cell Current Perspectives in β-Cell Development
Philip A. Seymour et al.
DIABETES (2011)
Islets Transplanted in Immunoisolation Devices: A Review of the Progress and the Challenges that Remain
Esther S. O'Sullivan et al.
ENDOCRINE REVIEWS (2011)
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming
James B. Papizan et al.
GENES & DEVELOPMENT (2011)
cMyc Is a Principal Upstream Driver of β-Cell Proliferation in Rat Insulinoma Cell Lines and Is an Effective Mediator of Human β-Cell Replication
Esra Karslioglu et al.
MOLECULAR ENDOCRINOLOGY (2011)
Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus
Franco Folli et al.
PLOS ONE (2011)
Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity
Chunyan Gu et al.
CELL METABOLISM (2010)
Pancreas vs. islet transplantation: a call on the future
Marina Vardanyan et al.
CURRENT OPINION IN ORGAN TRANSPLANTATION (2010)
Gestational Diabetes Mellitus Resulting From Impaired beta-Cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen
Hongjie Zhang et al.
DIABETES (2010)
β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes
Stephen C. Hanley et al.
ENDOCRINOLOGY (2010)
α Cell-Specific Men1 Ablation Triggers the Transdifferentiation of Glucagon-Expressing Cells and Insulinoma Development
Jieli Lu et al.
GASTROENTEROLOGY (2010)
FoxM1 Is Up-Regulated by Obesity and Stimulates β-Cell Proliferation
Dawn Belt Davis et al.
MOLECULAR ENDOCRINOLOGY (2010)
Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Fabrizio Thorel et al.
NATURE (2010)
Mesenchymal Stem Cell and Islet Co-Transplantation Promotes Graft Revascularization and Function
Taihei Ito et al.
TRANSPLANTATION (2010)
Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth
Myriam Solar et al.
DEVELOPMENTAL CELL (2009)
Prolactin Receptors Are Critical to the Adaptation of Islets to Pregnancy
Robert L. Sorenson et al.
ENDOCRINOLOGY (2009)
Prolactin Receptor Is Required for Normal Glucose Homeostasis and Modulation of β-Cell Mass during Pregnancy
Carol Huang et al.
ENDOCRINOLOGY (2009)
Bmi-1 regulates the Ink4a/Arf locus to control pancreatic β-cell proliferation
Sangeeta Dhawan et al.
GENES & DEVELOPMENT (2009)
The Transcriptional Response of the Islet to Pregnancy in Mice
Sebastian Rieck et al.
MOLECULAR ENDOCRINOLOGY (2009)
Why expression of some genes is disallowed in β-cells
Roell Quintens et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
β cells can be generated from endogenous progenitors in injured adult mouse pancreas
Xiaobo Xu et al.
CELL (2008)
β-Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1
Amanda Ackermann Misfeldt et al.
DIABETES (2008)
β-Cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans
Juris J. Meier et al.
DIABETES (2008)
Pancreatic β-cell mass in European subjects with type 2 diabetes
J. Rahier et al.
DIABETES OBESITY & METABOLISM (2008)
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
Mark P. Keller et al.
GENOME RESEARCH (2008)
Beneficial effects of lipids and prolactin on insulin secretion and β-cell proliferation:: a role for lipids in the adaptation of islets to pregnancy
T. Clark Brelje et al.
JOURNAL OF ENDOCRINOLOGY (2008)
Stimulation of human and rat islet β-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1
Jonathan C. Schisler et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Formation and regeneration of the endocrine pancreas
Sangeeta Dhawan et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
Growth and regeneration of adult β cells does not involve specialized progenitors
Monica Teta et al.
DEVELOPMENTAL CELL (2007)
Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis
Chien Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
p16INK4a induces an age-dependent decline in islet regenerative potential
Janakiraman Krishnamurthy et al.
NATURE (2006)
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
Kazutoshi Takahashi et al.
CELL (2006)
Relationship between β-cell mass and fasting blood glucose concentration in humans
RA Ritzel et al.
DIABETES CARE (2006)
The vascular basement membrane:: A niche for insulin gene expression and β cell proliferation
G Nikolova et al.
DEVELOPMENTAL CELL (2006)
Failure of transplanted bone marrow cells to adopt a pancreatic β-cell fate
J Taneera et al.
DIABETES (2006)
Growth factors and beta cell replication
RC Vasavada et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)
Very slow turnover of β-cells in aged adult mice
M Teta et al.
DIABETES (2005)
Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation
R Hull et al.
DIABETOLOGIA (2005)
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
JC Schisler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Cyclins D2 and D1 are essential for postnatal pancreatic β-cell growth
JA Kushner et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes
N Marzo et al.
DIABETOLOGIA (2004)
Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects
SP Deng et al.
DIABETES (2004)
In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4
S Hino et al.
DIABETOLOGIA (2004)
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Y Dor et al.
NATURE (2004)
Opposing actions of Arx and Pax4 in endocrine pancreas development
P Collombat et al.
GENES & DEVELOPMENT (2003)
Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells
JB Choi et al.
DIABETOLOGIA (2003)
Increased islet volume but unchanged islet number in ob/ob mice
T Bock et al.
DIABETES (2003)
Urocortin III is expressed in pancreatic β-cells and stimulates insulin and glucagon secretion
C Li et al.
ENDOCRINOLOGY (2003)
Bone marrow-derived stem cells initiate pancreatic regeneration
D Hess et al.
NATURE BIOTECHNOLOGY (2003)
In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
A Ianus et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
AE Butler et al.
DIABETES (2003)
Gestational diabetes and the incidence of type 2 diabetes - A systematic review
C Kim et al.
DIABETES CARE (2002)
Evidence for a circulating islet cell growth factor in insulin-resistant states
SN Flier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Linear correlation between β-cell mass and body weight throughout the lifespan in Lewis rats -: Role of β-cell hyperplasia and hypertrophy
E Montanya et al.
DIABETES (2000)
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.
AMJ Shapiro et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
G Gradwohl et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
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