期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms22063262
关键词
muscle; circRNA; RNA-binding protein; molecular interactions; function
资金
- National Natural Science Foundation of China [31772578, 32072715]
circRNA and their chaperoned RBPs play critical roles in biological functions, significantly contributing to normal animal development and disease. This review systematically characterizes the possible molecular mechanisms of circRNA-protein interactions, summarizes the latest research on circRNA-protein interactions in muscle development and myocardial disease, and discusses the future application of circRNA in treating muscle diseases.
Circular RNA (circRNA) is a kind of novel endogenous noncoding RNA formed through back-splicing of mRNA precursor. The biogenesis, degradation, nucleus-cytoplasm transport, location, and even translation of circRNA are controlled by RNA-binding proteins (RBPs). Therefore, circRNAs and the chaperoned RBPs play critical roles in biological functions that significantly contribute to normal animal development and disease. In this review, we systematically characterize the possible molecular mechanism of circRNA-protein interactions, summarize the latest research on circRNA-protein interactions in muscle development and myocardial disease, and discuss the future application of circRNA in treating muscle diseases. Finally, we provide several valid prediction methods and experimental verification approaches. Our review reveals the significance of circRNAs and their protein chaperones and provides a reference for further study in this field.
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