期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/ijms22073501
关键词
Salubrinal; collagen-induced arthritis; osteoclast; NF-κ B signaling pathway; P65
资金
- National Natural Science Foundation of China [81671590]
- National Key R&D Program of China [2019YFA0111000]
- Shanghai Science and Technology Committee [20ZR1448900]
- Shanghai Municipal Health Commission [202040121]
- Innovative research team of high-level local universities in Shanghai
Salubrinal treatment in CIA mice effectively reduces clinical scores, inhibits joint damage, and decreases the expression of destruction-related genes, showcasing its potential as a drug for RA and other bone destruction-related diseases.
Rheumatoid arthritis (RA) is a complex systemic autoimmune disorder that primarily involves joints, further affects the life quality of patients, and has increased mortality. The pathogenesis of RA involves multiple pathways, resulting in some patients showing resistance to the existing drugs. Salubrinal is a small molecule compound that has recently been shown to exert multiple beneficial effects on bone tissue. However, the effect of Salubrinal in RA has not been clearly confirmed. Hence, we induced collagen-induced arthritis (CIA) in DBA/1J mice and found that Salubrinal treatment decreased the clinical score of CIA mice, inhibiting joint damage and bone destruction. Furthermore, Salubrinal treatment downregulated osteoclast number in knee joint of CIA in mice, and suppressed bone marrow-derived osteoclast formation and function, downregulated osteoclast-related gene expression. Moreover, Salubrinal treatment inhibited RANKL-induced NF-kappa B signaling pathway, and promoted P65 degradation through the ubiquitin-proteasome system, further restrained RANKL-induced osteoclastogenesis. This study explains the mechanism by which Salubrinal ameliorates arthritis of CIA in mice, indicating that Salubrinal may be a potential drug for RA, and expands the potential uses of Salubrinal in the treatment of bone destruction-related diseases.
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