4.7 Review

The Multifaceted Roles of Ku70/80

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XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining

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Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair

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Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation

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Cryo-EM structure of human DNA-PK holoenzyme

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Human Ku70 protein binds hairpin RNA and double stranded DNA through two different sites

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VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair

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Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

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Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End Resection

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Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites

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Regulation of Ku-DNA Association by Yku70 C-terminal Tail and SUMO Modification

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Efficient processing of abasic sites by bacterial nonhomologous end-joining Ku proteins

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Finding the end: recruitment of telomerase to telomeres

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Putative binding modes of Ku70-SAP domain with double strand DNA: a molecular modeling study

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Removal of Shelterin Reveals the Telomere End-Protection Problem

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Yeast Nej1 Is a Key Participant in the Initial End Binding and Final Ligation Steps of Nonhomologous End Joining

Xi Chen et al.

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Structural Basis of Importin-α-Mediated Nuclear Transport for Ku70 and Ku80

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Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks

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TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends

Oriane Bombarde et al.

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Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

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Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton

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Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

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Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends

Steven A. Roberts et al.

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Ku86 represses lethal telomere deletion events in human somatic cells

Yongbao Wang et al.

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Ku antigen interacts with abasic sites

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Ku80 removal from DNA through double strand break-induced ubiquitylation

Lisa Postow et al.

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PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites

Jean-Francois Haince et al.

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Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination

Yu Zhang et al.

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PCNA, the maestro of the replication fork

George-Lucian Moldovan et al.

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Loading of the nonhomologous end joining factor, Ku, on protein-occluded DNA ends

Steven A. Roberts et al.

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Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs

Angel Rivera-Calzada et al.

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Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

Pierre-Olivier Mari et al.

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Parp-1 protects homologous recombination from interference by Ku and ligase IV in vertebrate cells

H Hochegger et al.

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A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization

XL Zhao et al.

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Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase

NSY Ting et al.

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Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

HY Cohen et al.

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The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR)

R Harris et al.

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Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing

R Roy et al.

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Cell cycle-dependent regulation of yeast telomerase by Ku

TS Fisher et al.

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Fluorescence anisotropy studies on the Ku-DNA interaction - Anion and cation effects

D Arosio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku

FD di Fagagna et al.

EMBO REPORTS (2003)

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Identification of a DNA nonhomologous end-joining complex in bacteria

GR Weller et al.

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Synapsis of DNA ends by DNA-dependent protein kinase

LG DeFazio et al.

EMBO JOURNAL (2002)

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Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK

LA Hanakahi et al.

EMBO JOURNAL (2002)

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Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs

YM Ma et al.

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Studies on the mode of Ku interaction with DNA

D Arosio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress

IS Ayene et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdfl/Hdf2 complexes

L Chen et al.

MOLECULAR CELL (2001)

Article Biochemistry & Molecular Biology

DNA length-dependent cooperative interactions in the binding of Ku to DNA

YM Ma et al.

BIOCHEMISTRY (2001)

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Identification of bacterial homologues of the Ku DNA repair proteins

AJ Doherty et al.

FEBS LETTERS (2001)

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Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe

KG Manolis et al.

EMBO JOURNAL (2001)

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The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku

SE Peterson et al.

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Ku acts in a unique way at the mammalian telomere to prevent end joining

HL Hsu et al.

GENES & DEVELOPMENT (2000)

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Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair

LA Hanakahi et al.