4.7 Review

The Urokinase Receptor: A Multifunctional Receptor in Cancer Cell Biology. Therapeutic Implications

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Rafting Down the Metastatic Cascade: The Role of Lipid Rafts in Cancer Metastasis, Cell Death, and Clinical Outcomes

Joshua D. Greenlee et al.

Summary: Lipid rafts, enriched microdomains within the plasma membrane, play crucial roles in cancer by regulating signal transduction, cell adhesion, migration, and oncogenic signaling, while also influencing different modes of cancer cell death. Their clinical significance lies in assessing patient prognosis and evaluating metastatic potential of cancers. Understanding the intricate roles of lipid rafts in the metastatic cascade may lead to therapeutic discoveries to inhibit prometastatic processes.

CANCER RESEARCH (2021)

Article Biochemistry & Molecular Biology

uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells

Alessio Biagioni et al.

Summary: This study demonstrates the crucial role of uPAR in the pro-angiogenic activity of melanoma Exos, with uPAR knockout reducing the angiogenic effects of Exos in vitro and in vivo. Inhibition of signaling pathways in endothelial cells, uPAR-EGFR interaction, and EGFR phosphorylation can all contribute to the reduction of melanoma Exos-induced angiogenesis. The identification of uPAR-expressing Exos as a potential biomarker for evaluating angiogenic propensity and treatment response in metastatic melanoma patients is suggested.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Chemistry, Medicinal

Small-Molecule Inhibition of the uPAR uPA Interaction by Conformational Selection

David Xu et al.

Summary: The study focused on designing and synthesizing derivatives for testing the binding and inhibition of the uPAR . uPA interaction. Through biophysical studies and molecular docking, the team found that the most effective way to inhibit uPAR binding to uPA with small molecules is by developing high-affinity compounds for the solution apo structures of uPAR, rather than uPA-bound structures of the receptor.

CHEMMEDCHEM (2021)

Article Gastroenterology & Hepatology

Plasma suPAR may help to distinguish between chronic pancreatitis and pancreatic cancer

Anu Aronen et al.

Summary: The study found that P-suPAR levels remained low in patients with chronic pancreatitis, but significantly higher in patients with pancreatic cancer. The levels of P-suPAR can be utilized to better differentiate between pancreatic cancer and chronic pancreatitis.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2021)

Article Chemistry, Medicinal

Design and Synthesis of Fragment Derivatives with a Unique Inhibition Mechanism of the uPAR•uPA Interaction

Khuchtumur Bum-Erdene et al.

Summary: A novel compound was discovered that could potentially inhibit the interaction between uPA and uPAR, leading to a conformational change in the receptor that prevents binding to uPA. Further studies are needed to determine if this unique inhibition mechanism can occur at the cell surface.

ACS MEDICINAL CHEMISTRY LETTERS (2021)

Review Endocrinology & Metabolism

The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer

Weiwei Liang et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Review Medicine, Research & Experimental

CXCL12/CXCR4 axis in the microenvironment of solid tumors: A critical mediator of metastasis

Keywan Mortezaee

LIFE SCIENCES (2020)

Review Radiology, Nuclear Medicine & Medical Imaging

Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer

V. M. Baart et al.

EJNMMI RESEARCH (2020)

Article Multidisciplinary Sciences

Senolytic CAR T cells reverse senescence-associated pathologies

Corina Amor et al.

NATURE (2020)

Article Medicine, Research & Experimental

Exploring the MIR143-UPAR Axis for the Inhibition of Human Prostate Cancer Cells In Vitro and In Vivo

Sven Wach et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Review Biochemistry & Molecular Biology

Cellular Senescence: The Sought or the Unwanted?

Yu Sun et al.

TRENDS IN MOLECULAR MEDICINE (2018)

Article Biochemistry & Molecular Biology

D2A sequence of the urokinase receptor induces cell growth through αvβ3 integrin and EGFR

Gabriele Eden et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Review Oncology

Epithelial-mesenchymal transition in tumor metastasis

Kay T. Yeung et al.

MOLECULAR ONCOLOGY (2017)

Article Oncology

uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells

Anna Laurenzana et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

Review Immunology

Regulation of inflammation by members of the formyl-peptide receptor family

Keqiang Chen et al.

JOURNAL OF AUTOIMMUNITY (2017)

Review Genetics & Heredity

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes

Chelsea L. Loughner et al.

HUMAN GENOMICS (2016)

Article Cell Biology

Urokinase receptor and CXCR4 are regulated by common microRNAs in leukaemia cells

Daniela Alfano et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2015)

Article Genetics & Heredity

Inhibition of uPAR-TGFβ crosstalk blocks MSC-dependent EMT in melanoma cells

Anna Laurenzana et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

Article Biochemistry & Molecular Biology

The interaction of uPAR with VEGFR2 promotes VEGF-induced angiogenesis

Stephanie Herkenne et al.

SCIENCE SIGNALING (2015)

Article Hematology

PTEN expression in endothelial cells is down-regulated by uPAR to promote angiogenesis

Matthias Unseld et al.

THROMBOSIS AND HAEMOSTASIS (2015)

Article Biochemistry & Molecular Biology

The interaction of uPAR with VEGFR2 promotes VEGF-induced angiogenesis

Stephanie Herkenne et al.

SCIENCE SIGNALING (2015)

Review Cell Biology

Pericellular proteolysis in cancer

Lisa Sevenich et al.

GENES & DEVELOPMENT (2014)

Article Multidisciplinary Sciences

Loss of Urokinase Receptor Sensitizes Cells to DNA Damage and Delays DNA Repair

Pavan B. Narayanaswamy et al.

PLOS ONE (2014)

Article Biochemistry & Molecular Biology

Network Analyses Reveal Pervasive Functional Regulation Between Proteases in the Human Protease Web

Nikolaus Fortelny et al.

PLOS BIOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2

Gretchen A. LaRusch et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)

Review Medicine, Research & Experimental

Role of Urokinase Receptor in Tumor Progression and Development

Hyangsoon Noh et al.

THERANOSTICS (2013)

Article Biochemistry & Molecular Biology

A Flexible Multidomain Structure Drives the Function of the Urokinase-type Plasminogen Activator Receptor (uPAR)

Haydyn D. T. Mertens et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

Basic and Therapeutic Aspects of Angiogenesis

Michael Potente et al.

Article Biochemistry & Molecular Biology

The cross-talk between the urokinase receptor and fMLP receptors regulates the activity of the CXCR4 chemokine receptor

Nunzia Montuori et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

Article Pharmacology & Pharmacy

The Urokinase-type Plasminogen Activator and the Generation of Inhibitors of Urokinase Activity and Signaling

Maria Vincenza Carriero et al.

CURRENT PHARMACEUTICAL DESIGN (2011)

Review Cell Biology

Four faces of cellular senescence

Francis Rodier et al.

JOURNAL OF CELL BIOLOGY (2011)

Article Chemistry, Multidisciplinary

Enhanced noscapine delivery using uPAR-targeted optical-MR imaging trackable nanoparticles for prostate cancer therapy

Mohamed O. Abdalla et al.

JOURNAL OF CONTROLLED RELEASE (2011)

Review Cell Biology

Regulation of cell signalling by uPAR

Harvey W. Smith et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Biochemical Research Methods

Targeting the Urokinase Plasminogen Activator Receptor with Synthetic Self-Assembly Nanoparticles

Ming Wang et al.

BIOCONJUGATE CHEMISTRY (2009)

Article Oncology

Receptor-Targeted Nanoparticles for In vivo Imaging of Breast Cancer

Lily Yang et al.

CLINICAL CANCER RESEARCH (2009)

Review Biotechnology & Applied Microbiology

suPAR: The molecular crystal ball

Maria Thuno et al.

DISEASE MARKERS (2009)

Article Biochemistry & Molecular Biology

Multiple activities of a multifaceted receptor: roles of cleaved and soluble uPAR

Nunzia Montuori et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2009)

Article Biochemistry & Molecular Biology

An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptor

Katia Bifulco et al.

FEBS LETTERS (2008)

Article Biochemistry & Molecular Biology

Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes

Qing Huai et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)

Article Cell Biology

uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells

Robin D. Lester et al.

JOURNAL OF CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

A region in urokinase plasminogen receptor domain III controlling a functional association with α5β1 integrin and tumor growth

Pratima Chaurasia et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Biochemistry & Molecular Biology

The urokinase receptor: a ligand or a receptor? Story of a sociable molecule

P. Ragno

CELLULAR AND MOLECULAR LIFE SCIENCES (2006)

Article Biochemistry & Molecular Biology

Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-β

J Kiyan et al.

EMBO JOURNAL (2005)

Review Hematology

Transcriptional and posttranscriptional regulation of the plasminogen activator system

Y Nagamine et al.

THROMBOSIS AND HAEMOSTASIS (2005)

Article Biochemistry & Molecular Biology

Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions

O Cunningham et al.

EMBO JOURNAL (2003)

Article Biochemistry & Molecular Biology

The cleavage of the urokinase receptor regulates its multiple functions

N Montuori et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R

M Resnati et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Identification of a urokinase receptor-integrin interaction site - Promiscuous regulator of integrin function

DI Simon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)