相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Neurotrophic interactions between neurons and astrocytes following AAV1-Rheb(S16H) transduction in the hippocampus in vivo
Min-Tae Jeon et al.
BRITISH JOURNAL OF PHARMACOLOGY (2020)
Role of Glial Cell Line-Derived Neurotrophic Factor in the Maintenance of Adult Mesencephalic Catecholaminergic Neurons
Daniel Enterria-Morales et al.
MOVEMENT DISORDERS (2020)
GDNF, A Neuron-Derived Factor Upregulated in Glial Cells during Disease
Marcelo Duarte Azevedo et al.
JOURNAL OF CLINICAL MEDICINE (2020)
Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain
Gyeong Joon Moon et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Induction of GDNF and GFRα-1 Following AAV1-Rheb(S16H) Administration in the Hippocampus in vivo
Dongyoung Yun et al.
EXPERIMENTAL NEUROBIOLOGY (2020)
Parkinson disease and the immune system - associations, mechanisms and therapeutics
Eng-King Tan et al.
NATURE REVIEWS NEUROLOGY (2020)
Protein transmission in neurodegenerative disease
Chao Peng et al.
NATURE REVIEWS NEUROLOGY (2020)
Treatment with AAV1-Rheb(S16H) provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke
Dongyeong Yoon et al.
NEUROREPORT (2020)
Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: implications for protection of striatal neurons expressing mutant huntingtin
Julieta Saba et al.
JOURNAL OF NEUROINFLAMMATION (2020)
GDNF/RETSignaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons
Piotr Chmielarz et al.
MOVEMENT DISORDERS (2020)
Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation
Pedro Norat et al.
NPJ REGENERATIVE MEDICINE (2020)
Serum level of brain-derived neurotrophic factor in Parkinson's disease: a meta-analysis
Lina Jiang et al.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2019)
Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease
Alan Whone et al.
BRAIN (2019)
Plasma levels of brain-derived neurotrophic factor in patients with Parkinson disease: A systematic review and meta-analysis
Farzaneh Rahmani et al.
BRAIN RESEARCH (2019)
Extended Treatment with Glial Cell Line-Derived Neurotrophic Factor in Parkinson's Disease
Alan L. Whone et al.
JOURNAL OF PARKINSONS DISEASE (2019)
Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles
Richard M. Meade et al.
MOLECULAR NEURODEGENERATION (2019)
Neuroinflammation - a common thread in neurological disorders
Nils Erik Gilhus et al.
NATURE REVIEWS NEUROLOGY (2019)
Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease
Zhi-Hao Wang et al.
CELL REPORTS (2019)
Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion Through GDNF/GFRα1/Ret Signaling Preventing Hippocampal Neuron Apoptosis
Wenxian Li et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
The Impairments of α-Synuclein and Mechanistic Target of Rapamycin in Rotenone-Induced SH-SY5Y Cells and Mice Model of Parkinson's Disease
Mahesh Ramalingam et al.
FRONTIERS IN NEUROSCIENCE (2019)
Therapeutic Potential of AAV1-Rheb(S16H) Transduction Against Alzheimer's Disease
Gyeong Joon Moon et al.
JOURNAL OF CLINICAL MEDICINE (2019)
Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
Michael G. Erkkinen et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)
The cholinergic system in the pathophysiology and treatment of Alzheimer's disease
Harald Hampel et al.
BRAIN (2018)
Proteome points to synaptic dysfunction in dementia
Charlotte Ridler
NATURE REVIEWS NEUROLOGY (2018)
Tau-targeting therapies for Alzheimer disease
Erin E. Congdon et al.
NATURE REVIEWS NEUROLOGY (2018)
Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3
Anna Sergeevna Sowa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Selective vulnerability in neurodegenerative diseases
Hongjun Fu et al.
NATURE NEUROSCIENCE (2018)
Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model
Lorenzo Schiaffino et al.
SCIENTIFIC REPORTS (2018)
Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington's Disease
Chenglong Yu et al.
SCIENTIFIC REPORTS (2018)
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Przemyslaw Kowianski et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2018)
Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo
Sehwan Kim et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2018)
Brain-Derived Neurotrophic Factor Facilitates Functional Recovery from ALS-Cerebral Spinal Fluid-Induced Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line
Shanmukha Shruthi et al.
NEURODEGENERATIVE DISEASES (2017)
In Vitro Modulation of TrkB Receptor Signaling upon Sequential Delivery of Curcumin-DHA Loaded Carriers Towards Promoting Neuronal Survival
Luis P. B. Guerzoni et al.
PHARMACEUTICAL RESEARCH (2017)
Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1G93A ALS rat but has adverse side effects
G. M. Thomsen et al.
GENE THERAPY (2017)
Epidemiology of Parkinson's disease
Ole-Bjorn Tysnes et al.
JOURNAL OF NEURAL TRANSMISSION (2017)
Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models
Xiaomin Su et al.
MOLECULAR THERAPY (2017)
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
Yvette C. Wong et al.
NATURE MEDICINE (2017)
ER stress and the unfolded protein response in neurodegeneration
Claudio Hetz et al.
NATURE REVIEWS NEUROLOGY (2017)
Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy
Tuane Bazanella Sampaio et al.
NEURAL REGENERATION RESEARCH (2017)
Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice
Neelam Shahani et al.
NEUROBIOLOGY OF AGING (2017)
TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease
Seong Su Kang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Pathology of Neurodegenerative Diseases
Brittany N. Dugger et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)
Parkinson disease
Werner Poewe et al.
NATURE REVIEWS DISEASE PRIMERS (2017)
Role of Neurotrophic Factors in Parkinson's Disease
Diogo Tome et al.
CURRENT PHARMACEUTICAL DESIGN (2017)
Disruption of the astrocytic TNFR1-GDNF axis accelerates motor neuron degeneration and disease progression in amyotrophic lateral sclerosis
Liliana Brambilla et al.
HUMAN MOLECULAR GENETICS (2016)
Cholinergic Interneurons in the Q140 Knockin Mouse Model of Huntington's Disease: Reductions in Dendritic Branching and Thalamostriatal Input
Yun-Ping Deng et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2016)
Decoding ALS: from genes to mechanism
J. Paul Taylor et al.
NATURE (2016)
The road to restoring neural circuits for the treatment of Alzheimer's disease
Rebecca G. Canter et al.
NATURE (2016)
Ageing, neurodegeneration and brain rejuvenation
Tony Wyss-Coray
NATURE (2016)
Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer's pathology
Taylor W. Schmitz et al.
NATURE COMMUNICATIONS (2016)
Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson's Disease
Ching-Hsiang Fan et al.
SCIENTIFIC REPORTS (2016)
Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease
S-S Jiao et al.
TRANSLATIONAL PSYCHIATRY (2016)
Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain
Guohui Jiang et al.
CLINICAL SCIENCE (2015)
Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling
Shanshan Gao et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2015)
Expressing Constitutively Active Rheb in Adult Neurons after a Complete Spinal Cord Injury Enhances Axonal Regeneration beyond a Chondroitinase-Treated Glial Scar
Di Wu et al.
JOURNAL OF NEUROSCIENCE (2015)
In Vivo AAV1 Transduction With hRheb(S16H) Protects Hippocampal Neurons by BDNF Production
Min-Tae Jeon et al.
MOLECULAR THERAPY (2015)
Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias
Perdita Cheshire et al.
MOVEMENT DISORDERS (2015)
GDNF is not required for catecholaminergic neuron survival in vivo
Jaakko Kopra et al.
NATURE NEUROSCIENCE (2015)
Reinstating Aberrant mTORC1 Activity in Huntington's Disease Mice Improves Disease Phenotypes
John H. Lee et al.
NEURON (2015)
mTOR IN BRAIN PHYSIOLOGY AND PATHOLOGIES
Joel Bockaert et al.
PHYSIOLOGICAL REVIEWS (2015)
Activation of CNTF/CNTFRα Signaling Pathway by hRheb(S16H) Transduction of Dopaminergic Neurons In Vivo
Kyoung Hoon Jeong et al.
PLOS ONE (2015)
Regulation of mTORC1 by PI3K signaling
Christian C. Dibble et al.
TRENDS IN CELL BIOLOGY (2015)
Conditional targeting of medium spiny neurons in the striatal matrix
Bjorn Reinius et al.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2015)
Neuroinflammation in Parkinson's disease and its potential as therapeutic target
Qinqin Wang et al.
TRANSLATIONAL NEURODEGENERATION (2015)
Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer
Raynoo Thanan et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)
Induction of GDNF and BDNF by hRheb(S16H) Transduction of SNpc Neurons: Neuroprotective Mechanisms of hRheb(S16H) in a Model of Parkinson's Disease
Jin Han Nam et al.
MOLECULAR NEUROBIOLOGY (2015)
Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis
Qian Zhou et al.
TOXICOLOGICAL SCIENCES (2015)
Roles of Rheb(S16H) in substantia nigra pars compacta dopaminergic neurons in vivo
Min-Tae Jeon et al.
BIOMEDICAL REPORTS (2015)
Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease
Chandana Buddhala et al.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2015)
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
Aaron Ciechanover et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2015)
Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
Ariadna Recasens et al.
ANNALS OF NEUROLOGY (2014)
Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease
Helene Hall et al.
BRAIN (2014)
Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
Yijiao Xu et al.
CELLULAR SIGNALLING (2014)
Rheb GTPase Regulates β-Secretase Levels and Amyloid β Generation
Neelam Shahani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Deficiency of GDNF Receptor GFRα1 in Alzheimer's Neurons Results in Neuronal Death
Yoshihiro Konishi et al.
JOURNAL OF NEUROSCIENCE (2014)
Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain
Susana Revilla et al.
NEUROPHARMACOLOGY (2014)
7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis
Orhan Tansel Korkmaz et al.
NEUROSCIENCE LETTERS (2014)
The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
Azadeh A. Rikani et al.
ANNALS OF NEUROSCIENCES (2014)
Cholinergic Dysfunction in Parkinson's Disease
Martijn L. T. M. Mueller et al.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2013)
Controversies and priorities in amyotrophic lateral sclerosis
Martin R. Turner et al.
LANCET NEUROLOGY (2013)
Control of A beta release from human neurons by differentiation status and RET signaling
Diana Scholz et al.
NEUROBIOLOGY OF AGING (2013)
BENEFITS OF PUTAMINAL GDNF INFUSION IN PARKINSON DISEASE ARE MAINTAINED AFTER GDNF CESSATION
Nikunj K. Patel et al.
NEUROLOGY (2013)
Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF
Ofelia M. Littrell et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2013)
Neurotoxin-Induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling
Senthil Selvaraj et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Cooperative action of JNK and AKT/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells
Jezabel Rodriguez-Blanco et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2012)
TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
Christian C. Dibble et al.
MOLECULAR CELL (2012)
AAV Transduction of Dopamine Neurons With Constitutively Active Rheb Protects From Neurodegeneration and Mediates Axon Regrowth
Sang Ryong Kim et al.
MOLECULAR THERAPY (2012)
α-Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons
Mickael Decressac et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Dopaminergic Pathway Reconstruction by Akt/Rheb-Induced Axon Regeneration
Sang Ryong Kim et al.
ANNALS OF NEUROLOGY (2011)
GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease
Mickael Decressac et al.
BRAIN (2011)
Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models
Andrii Domanskyi et al.
FASEB JOURNAL (2011)
Akt Suppresses Retrograde Degeneration of Dopaminergic Axons by Inhibition of Macroautophagy
Hsiao-Chun Cheng et al.
JOURNAL OF NEUROSCIENCE (2011)
Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling
Claus Rieker et al.
JOURNAL OF NEUROSCIENCE (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease
Chiara Zuccato et al.
PLOS ONE (2011)
A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death
Kyou-Chan Choi et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson's disease
Paula Scalzo et al.
JOURNAL OF NEUROLOGY (2010)
Ciliary Neurotrophic Factor Cell-Based Delivery Prevents Synaptic Impairment and Improves Memory in Mouse Models of Alzheimer's Disease
Pierre Garcia et al.
JOURNAL OF NEUROSCIENCE (2010)
Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells
Long Chen et al.
LABORATORY INVESTIGATION (2010)
MECHANISMS OF DISEASE Alzheimer's Disease
Henry W. Querfurth et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy
Leslie Crews et al.
PLOS ONE (2010)
Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications
Rebecca Banerjee et al.
TRENDS IN NEUROSCIENCES (2010)
Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand?
Alexandre Henriques et al.
FRONTIERS IN NEUROSCIENCE (2010)
Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases
Xiao-xia Dong et al.
ACTA PHARMACOLOGICA SINICA (2009)
Glial Cell-Line Derived Neurotrophic Factor (GDNF) Concentrations in Cerebrospinal Fluid and Serum of Patients with Early Alzheimer's Disease and Normal Controls
Guido Straten et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
Alan H. Nagahara et al.
NATURE MEDICINE (2009)
RAPAMYCIN PROTECTS AGAINST ROTENONE-INDUCED APOPTOSIS THROUGH AUTOPHAGY INDUCTION
T. Pan et al.
NEUROSCIENCE (2009)
Role of mTOR in physiology and pathology of the nervous system
Lukasz Swiech et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2008)
Tuberous sclerosis complex proteins control axon formation
Yong-Jin Choi et al.
GENES & DEVELOPMENT (2008)
Rheb and mTOR Regulate Neuronal Polarity through Rap1B
Ying-Hua Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation
Cristina Malagelada et al.
JOURNAL OF NEUROSCIENCE (2008)
Small molecule enhancers of autophagy for neurodegenerative diseases
Sovan Sarkar et al.
MOLECULAR BIOSYSTEMS (2008)
Absolute requirement of GDNF for adult catecholaminergic neuron survival
Alberto Pascual et al.
NATURE NEUROSCIENCE (2008)
Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Kevin Kyungsuk Park et al.
SCIENCE (2008)
Long-term survival of encapsulated GDNF secreting cells implanted within the striatum of parkinsonized rats
Laura Grandoso et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2007)
Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal
John T. Slevin et al.
JOURNAL OF NEUROSURGERY (2007)
CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo
Jason F. Talbott et al.
EXPERIMENTAL NEUROLOGY (2007)
The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington's chorea
Philippe Huot et al.
BRAIN (2007)
Small molecule neurotrophin receptor ligands: Novel strategies for targeting Alzheimer's disease mechanisms
Frank M. Longo et al.
CURRENT ALZHEIMER RESEARCH (2007)
The growing role of mTOR in neuronal development and plasticity
Jacek Jaworski et al.
MOLECULAR NEUROBIOLOGY (2006)
The roles of intracellular protein-degradation pathways in neurodegeneration
David C. Rubinsztein
NATURE (2006)
Mechanisms of Parkinson's disease linked to pathological α-synuclein:: New targets for drug discovery
Virginia M. -Y. Lee et al.
NEURON (2006)
Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations:: Potential factors in amyloid plaque formation
Holly Oakley et al.
JOURNAL OF NEUROSCIENCE (2006)
Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase
J. Avruch et al.
ONCOGENE (2006)
RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation
Cristina Malagelada et al.
JOURNAL OF NEUROSCIENCE (2006)
Protecting motor neurons from toxic insult by antagonism of adenosine A2a and Trk receptors
Jelena Mojsilovic-Petrovic et al.
JOURNAL OF NEUROSCIENCE (2006)
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
AE Lang et al.
ANNALS OF NEUROLOGY (2006)
Regulation of microglial activities by glial cell line derived neurotrophic factor
YP Chang et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2006)
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
SF Tavazoie et al.
NATURE NEUROSCIENCE (2005)
Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways
RD Almeida et al.
CELL DEATH AND DIFFERENTIATION (2005)
Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain
S Love et al.
NATURE MEDICINE (2005)
Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms
J Lee et al.
EXPERIMENTAL NEUROLOGY (2005)
Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease
SY Peng et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Structural basis for the unique biological function of small GTPase RHEB
YD Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Novel role of the small GTPase Rheb: Its implication in endocytic pathway independent of the activation of mammalian target of rapamycin
K Saito et al.
JOURNAL OF BIOCHEMISTRY (2005)
Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
JT Slevin et al.
JOURNAL OF NEUROSURGERY (2005)
Enprofylline Protects Motor Neurons from in vitro Excitotoxic Challenge
Jelena Mojsilovic-Petrovic et al.
NEURODEGENERATIVE DISEASES (2005)
The Rheb family of GTP-binding proteins
PJ Aspuria et al.
CELLULAR SIGNALLING (2004)
Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease
JM Canals et al.
JOURNAL OF NEUROSCIENCE (2004)
Drug therapy - Alzheimer's disease
JL Cummings
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease
C Lo Bianco et al.
NEUROBIOLOGY OF DISEASE (2004)
Early Alzheimer's disease
CH Kawas
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Drosophila Rheb GTPase is required for cell cycle progression and cell growth
PH Patel et al.
JOURNAL OF CELL SCIENCE (2003)
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
SS Gill et al.
NATURE MEDICINE (2003)
BDNF heightens the sensitivity of motor neurons to excitotoxic insults through activation of TrkB
P Hu et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
JG Nutt et al.
NEUROLOGY (2003)
Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches
H Thoenen et al.
NATURE NEUROSCIENCE (2002)
Elevated levels of neurotrophins in human biceps brachii tissue of amyotrophic lateral sclerosis
BM Küst et al.
EXPERIMENTAL NEUROLOGY (2002)
Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation
P. F. Behrens et al.
BRAIN (2002)
From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS
DW Cleveland et al.
NATURE REVIEWS NEUROSCIENCE (2001)
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
C Zuccato et al.
SCIENCE (2001)
BDNF and epilepsy: too much of a good thing?
DK Binder et al.
TRENDS IN NEUROSCIENCES (2001)
Neurotrophins: Roles in neuronal development and function
EJ Huang et al.
ANNUAL REVIEW OF NEUROSCIENCE (2001)
Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra
DW Howells et al.
EXPERIMENTAL NEUROLOGY (2000)
GDNF but not BDNF is increased in cerebrospinal fluid in amyotrophic lateral sclerosis
E Grundström et al.
NEUROREPORT (2000)
Region-specific neurotrophin imbalances in Alzheimer disease Decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas
C Hock et al.
ARCHIVES OF NEUROLOGY (2000)
Brain-derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3-kinase pathway
HJL Fryer et al.
JOURNAL OF NEUROCHEMISTRY (2000)