期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms22105177
关键词
embryo implantation; mouse; single-cell RNA-seq; transcriptional changes
资金
- National Natural Science Foundation of China [32070845, 31771665]
- Guangdong Natural Science Funds for Distinguished Young Scholars [2021B1515020079]
- Innovation TeamProject of Guangdong University [2019KCXTD001]
The research team generated a single-cell transcriptomic atlas of embryo implantation sites in mice, identifying global gene expression changes associated with embryo implantation. They predicted signaling interactions between uterine luminal epithelial cells and mural trophectoderm of blastocysts, as well as between uterine epithelial-stromal crosstalk at implantation sites.
As a crucial step for human reproduction, embryo implantation is a low-efficiency process. Despite rapid advances in recent years, the molecular mechanism underlying embryo implantation remains poorly understood. Here, we used the mouse as an animal model and generated a single-cell transcriptomic atlas of embryo implantation sites. By analyzing inter-implantation sites of the uterus as control, we were able to identify global gene expression changes associated with embryo implantation in each cell type. Additionally, we predicted signaling interactions between uterine luminal epithelial cells and mural trophectoderm of blastocysts, which represent the key mechanism of embryo implantation. We also predicted signaling interactions between uterine epithelial-stromal crosstalk at implantation sites, which are crucial for post-implantation development. Our data provide a valuable resource for deciphering the molecular mechanism underlying embryo implantation.
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