期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms22094728
关键词
USP15; TGF-beta; BMP; NF-kappa B; Wnt/beta-catenin; CSN; p53; IGF; Nrf2-Keap1; RNA splicing
资金
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2017R1A2B3007224, 2019R1A2C2004052, 2020R1A4A4079494]
- Brain Pool Program through the National Research Foundation of Korea - Ministry of Science and ICT [2017HID3A1A02054608]
- National Research Foundation of Korea [2020R1A4A4079494] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This review discusses the important role of deubiquitinase USP15 in various signaling pathways, highlighting its mechanisms in regulating protein stability and signal transduction processes. Understanding the regulatory mechanisms of USP15 can provide important insights into possible disease markers and clinical applications.
Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore, some of the enzymes involved in ubiquitination and deubiquitination, particularly E3 ligases and deubiquitinases, have attracted attention for drug discovery. Here, we review recent findings on USP15, one of the deubiquitinases, which regulates diverse signaling pathways by deubiquitinating vital target proteins. Even though several basic previous studies have uncovered the versatile roles of USP15 in different signaling networks, those have not yet been systematically and specifically reviewed, which can provide important information about possible disease markers and clinical applications. This review will provide a comprehensive overview of our current understanding of the regulatory mechanisms of USP15 on different signaling pathways for which dynamic reverse ubiquitination is a key regulator.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据